ID   MUTL_THEAB              Reviewed;         568 AA.
AC   B7IHA2;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=THA_1008;
OS   Thermosipho africanus (strain TCF52B).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX   NCBI_TaxID=484019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TCF52B;
RX   PubMed=19124572; DOI=10.1128/jb.01448-08;
RA   Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA   Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT   "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT   the Firmicutes and Archaea.";
RL   J. Bacteriol. 191:1974-1978(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001185; ACJ75466.1; -; Genomic_DNA.
DR   RefSeq; WP_012579927.1; NC_011653.1.
DR   AlphaFoldDB; B7IHA2; -.
DR   SMR; B7IHA2; -.
DR   STRING; 484019.THA_1008; -.
DR   EnsemblBacteria; ACJ75466; ACJ75466; THA_1008.
DR   KEGG; taf:THA_1008; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002453; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..568
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192187"
SQ   SEQUENCE   568 AA;  65206 MW;  A9D79289089E3FD5 CRC64;
     MGKIKKLPEH VIGKIAAGEV VAGPYSVVKE LVENSLDAGA TKIEIEIKSG GKSYIKVKDN
     GEGMGREDLL LSIYEHTTSK INDFDDIYNL SSFGFRGEAL ASIAKVSRIV ITSNNGSESH
     RLEAIGGKIK SVNEYPLVEK GTIVEVYDLF FNVPARRKFL KSEATEKRYV VEYVEKFLLS
     NPDVEFIFRA DNEIIYNARA SNLEERFKLI FPEVKEYTLI NGKYVEGIIS SPNYHRKNRT
     GQIFFVQKRF VMDKMLYYIF ENGYGEALVD HPYGVLFINV PSKLVDVNVH PQKLEVKFSN
     PNIIYSDITR TVREALKKFV SKQIFVKPIN EKKTKSEVSS FETKNVNFSN DSFQDKFNSV
     FKESVNHVDY SKNMLFDISE KNLEVKNDVV ILKKRYVLFE MEDGIYIMDF HAAHERVIYE
     QILEKLKVGI EKIDLIIPIE IKVGKSLKQI VIEKLDELKE NGFEIKVENE SVKILSIPSF
     IKPSDVDDIF KEIIDEYRIP SMGTKNMKHI IADKACKSAV RTGYDITEGE AKKLIEEVFK
     RNLTTCPHGR PLFLKITFNE IDKYFDRT