ID   MUTL_THEAQ              Reviewed;         533 AA.
AC   P96082;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL;
OS   Thermus aquaticus.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25104 / DSM 625 / JCM 10724 / NBRC 103206 / NCIMB 11243 / YT-1;
RA   Yamamoto A., Biswas I., Hsieh P.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
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DR   EMBL; U50453; AAB40601.1; -; Genomic_DNA.
DR   RefSeq; WP_053767725.1; NZ_LHCI01000106.1.
DR   AlphaFoldDB; P96082; -.
DR   SMR; P96082; -.
DR   PRIDE; P96082; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..533
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177984"
FT   REGION          510..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   533 AA;  58537 MW;  4442F9BB7A6CB8A4 CRC64;
     MIRPLPPELR GLLARGEVLL SVKDAVRELL ENALDAGARR VRVELWGGGL ERIVVEDDGE
     GIPLEELPLA VEPFATSKLQ DLERIATLGF RGQALYALRQ AATLKIRSRP RGQVGGGLLL
     ARGERVELRP APAPPGTRVE VLGLFAGEGR DPKAEARGVL DLLKRYLLHH PHLSLVLFLE
     GEARLLFPGA GLKEAARQAF GGLLAERLFP LEKGGAFALE GLLTGPQVSR TRPDLLFLAV
     NGRPVALPEG VLRAVRRAYR ELLPEGHYPV GVLNLSLPPG AYRLRLDARK EEVALSKEAE
     AFLEEALEEA FRGQNLARAL PEPRPLPALR PPPLPACPPC ATWATFRESY LLAEAEDAVY
     IVDQHAAHER ILFEELLARL REEGLKPLPY PVLVELDEEP PEASPLFGIE GFGPGRVRLL
     SAPPFLHPYP LLPPEIFRES LKGEGRSRLR GLLARLACLP ALKAGHPLAR AEGQALLDAL
     LACETPWVCP HGRPVLLHLK EEDLIRRFGR RSGARAKEEP HPHPPRETTR EGS