ID   MUTL_THEM4              Reviewed;         551 AA.
AC   A6LL30;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Tmel_0769;
OS   Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429).
OC   Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX   NCBI_TaxID=391009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12029 / CIP 104789 / BI429;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA   Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermosipho melanesiensis BI429.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000716; ABR30631.1; -; Genomic_DNA.
DR   RefSeq; WP_012056992.1; NC_009616.1.
DR   AlphaFoldDB; A6LL30; -.
DR   SMR; A6LL30; -.
DR   STRING; 391009.Tmel_0769; -.
DR   PRIDE; A6LL30; -.
DR   EnsemblBacteria; ABR30631; ABR30631; Tmel_0769.
DR   KEGG; tme:Tmel_0769; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_3_0; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001110; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..551
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192188"
SQ   SEQUENCE   551 AA;  63417 MW;  41BFEC23CA75806B CRC64;
     MGKIKKLDKN VVSRIAAGEA VAGPFSVVKE LVENALDASA TKIEIEILNG GKSYIKVKDN
     GEGMSRDDLL LSIEEHTTSK IEDFEDIYNL YSFGFRGEAL SSISKVSKLV ITSNDGKESN
     RLEVIGGKIK DIKEYPTSEK GTIVEVYDLF FNVPARRKFL KSDNVEKRYV VEYVEKFLLG
     NPDVEIVLKS DGEVVYNAVK GNLEDRFRLI FPEVREFTEV SGKYVKGIIS SPSYYRNNRT
     GQIFFVQKRF VIDKMLYYIF ETGYGEALLK HPYGVLFIEV PPRFVDVNVH PQKLEVKFSN
     PNVIYSDITR TVREGIKKFV SKKIFVKKEQ NTVNENKLNY AYGPKSKPFQ TNIEKNMLFN
     VEKKQLEVKR DIVVLKKRYV LFESNDGIYI MDFHAAHERI LYDNIIKQLD EKVERLDLMI
     PIEIKIGKSF LQIAEGRKED FKRFGFNIKI DKEKIIVLSI PSFIKPSDVV EVLMEILDEY
     RILGENPKSM KHIIADKACK KAVKTGYDIL ESEAKQLVEE VLKRGLTTCP HGRPLFLKIT
     YKELDSFFER T