ID   MUTL_THEMA              Reviewed;         510 AA.
AC   P74925; Q9S5W9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=DNA mismatch repair protein MutL;
GN   Name=mutL; OrderedLocusNames=TM_0022;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Wetmur J.G., Rosenfeld A., Wong D.M.;
RT   "Expression and characterization of MutL proteins from thermophilic
RT   eubacteria.";
RL   Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD35116.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U71053; AAB09596.1; -; Genomic_DNA.
DR   EMBL; AE000512; AAD35116.1; ALT_INIT; Genomic_DNA.
DR   PIR; H72427; H72427.
DR   RefSeq; NP_227838.1; NC_000853.1.
DR   AlphaFoldDB; P74925; -.
DR   SMR; P74925; -.
DR   STRING; 243274.THEMA_04690; -.
DR   PRIDE; P74925; -.
DR   EnsemblBacteria; AAD35116; AAD35116; TM_0022.
DR   KEGG; tma:TM0022; -.
DR   eggNOG; COG0323; Bacteria.
DR   InParanoid; P74925; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..510
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177985"
SQ   SEQUENCE   510 AA;  59021 MW;  19FAE9EDE8986F47 CRC64;
     MRIKRLPESL VRKIAAGEVI HNPSFVLKEL VENSLDAQAD RIVVEIENGG KNMVRVSDNG
     IGMTREEALL AIEPYTTSKI ESEEDLHRIR TYGFRGEALA SIVQVSRAKI VTKTEKDALA
     TQLMIAGGKV EEISETHRDT GTTVEVRDLF FNLPVRRKSL KSSAIELRMC REMFERFVLV
     RNDVDFVFTS DGKIVHSFPR TQNIFERALL ILEDLRKGYI TFEEELSGLR IKGIVSSREV
     TRSSRTGEYF YVNGRFVVSE ELHEVLMKVY DLPKRSYPVA VLFIEVNPEE LDVNIHPSKI
     VVKFLNEEKV KKSLEETLKR NLARKWYRSV AYEEISSRAL SVAEAPSHRW FLVKGKYAVV
     EVEDGLLFVD LHALHERTIY EEILSKKSWG KRRVKRNITV VLSREEKQKL EEYGFSFQGE
     EGALKVIEIP EFLTEDVVEE FFRDFPVDEK LKERIALAAC KLATKSGEFD EEIASKLLDV
     FFKKRFERCP HGRPISFKIS YEDMDRFFER