ID   MUTL_THEP3              Reviewed;         614 AA.
AC   B0K9L6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Teth39_1175;
OS   Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) (Clostridium
OS   thermohydrosulfuricum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacter.
OX   NCBI_TaxID=340099;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33223 / DSM 2355 / 39E;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Saunders E., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Hemme C., Fields M.W., He Z., Zhou J.,
RA   Richardson P.;
RT   "Complete sequence of Thermoanaerobacter pseudethanolicus 39E.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000924; ABY94829.1; -; Genomic_DNA.
DR   RefSeq; WP_012269346.1; NC_010321.1.
DR   AlphaFoldDB; B0K9L6; -.
DR   SMR; B0K9L6; -.
DR   STRING; 340099.Teth39_1175; -.
DR   PRIDE; B0K9L6; -.
DR   EnsemblBacteria; ABY94829; ABY94829; Teth39_1175.
DR   KEGG; tpd:Teth39_1175; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_9; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002156; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..614
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096695"
SQ   SEQUENCE   614 AA;  70264 MW;  44A85B206B85F243 CRC64;
     MNKIHLLDEK TINKISAGEV VERPASIVKE LIENSIDAGS KNITVEILEG GIPYIKVSDD
     GCGMNEIDAI LAFERHATSK IKSDNDLYSI GTLGFRGEAL ASIAAVSHVT LQTKEEGALF
     GTKVVVEGGK VVEKTTCGCA KGCSIEVRDV FFNTPARRKF LKRPSTESMY ITDVVTKLCL
     SHPEVSFKYV KDRKLQFITS GNGNIEDVIL RLFGNEVYSS LMSASFESED LKLKILAGKN
     SLNYSNRNMQ FFYVNGRYVK NKTLSAAVDE AFKTYIPVNR YPAVFLYMEI DPRQIDVNIH
     PSKLEIKFSD ERRIFEAVYK TIKDSLHKYN LIPEVKIEEK KNIFEIETPT ISAEQTKLYF
     TSSDKEVEKE KKKFDNEFKG KNVFLKDNVL KENSKNSSLD NHLAVYEEYE HEKEEINKND
     LAKKISDIRI VGTLFSTYII VEKEDVFYII DQHAAHERIL YEKFTSQYEK IQTRQVTFPI
     VVELQPRDLE LVHQEKELLN KLGYVFEEFG NNSIILREVP VILGQPEARQ LFIDIVEKLK
     DKELVNKISL KEENIIMMAC KAAVKAMDNL SEKEINKLFD DLKITENPYT CPHGRPVIIA
     ITKTQLEKMF KRIM