ID   MUTL_THET8              Reviewed;         545 AA.
AC   Q9RA54; Q5SIP6;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=TTHA1323;
OS   Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=300852;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Shiba F., Kato R., Kuramitsu S.;
RT   "Mismatch repair enzyme, MutL, from an extremely thermophilic bacterium.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27634 / DSM 579 / HB8;
RA   Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA   Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT   "Complete genome sequence of Thermus thermophilus HB8.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AB020210; BAA87903.1; -; Genomic_DNA.
DR   EMBL; AP008226; BAD71146.1; -; Genomic_DNA.
DR   RefSeq; WP_011228596.1; NC_006461.1.
DR   RefSeq; YP_144589.1; NC_006461.1.
DR   AlphaFoldDB; Q9RA54; -.
DR   SMR; Q9RA54; -.
DR   STRING; 300852.55772705; -.
DR   EnsemblBacteria; BAD71146; BAD71146; BAD71146.
DR   GeneID; 3169099; -.
DR   KEGG; ttj:TTHA1323; -.
DR   PATRIC; fig|300852.9.peg.1301; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   OMA; AHERIMY; -.
DR   PhylomeDB; Q9RA54; -.
DR   Proteomes; UP000000532; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..545
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177986"
FT   REGION          517..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        455
FT                   /note="S -> T (in Ref. 1; BAA87903)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   545 AA;  60103 MW;  A198699EA033A4C3 CRC64;
     MIRPLPPELR GLLARGEVLL TVKDAVRELL ENALDAGARR VRVELWGGGL KRLVVEDDGE
     GIPLEDLPLA VEPYATSKLQ DLEGIRTLGF RGQALYALRQ AARLRIRSRP RGQLGGGLLL
     AEGERVEVRP VPAPPGTRVE VEGLFLGEGR DPKGEVRGVL ELLKRYLLHH PRLALALFAE
     GEARLLFPGA GLEEAARLAF GRLLAKRLLP LAYGAGGLEV QGLVSRPEVS RTRPDRLFLA
     VNGRPVAFPE GLLRRVRRAY RELLPEGHYP VGVLNLFLPQ EAFRLRLDAR KEEVVLSEEV
     EALVEEALLA LFRRENLARA LPEPKPLQPL SPPTASGLPR LRFLAQFRES YLLAEAGDTL
     YVVDQHAAHE RILYEDLLKR VAEGPKPLPR PLLVPLAPEE EALLEAGQEA LAALFRWEPF
     GPGRVRLLMA PAFLHPYPLL LPEVFKEALR GEGRSLKALL ARLACLPAVK AGHPLGEAQG
     QALLDALLAC ETPWACPHGR PVLLALKEED LIRRFGRRSG ARGGGEARPR PQEESFPEAP
     LPREP