ID   MUTL_THEYD              Reviewed;         544 AA.
AC   B5YIZ6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=THEYE_A2083;
OS   Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87).
OC   Bacteria; Nitrospirae; Thermodesulfovibrionia; Thermodesulfovibrionales;
OC   Thermodesulfovibrionaceae; Thermodesulfovibrio.
OX   NCBI_TaxID=289376;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51303 / DSM 11347 / YP87;
RA   Dodson R.J., Durkin A.S., Wu M., Eisen J., Sutton G.;
RT   "The complete genome sequence of Thermodesulfovibrio yellowstonii strain
RT   ATCC 51303 / DSM 11347 / YP87.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001147; ACI21459.1; -; Genomic_DNA.
DR   RefSeq; WP_012546175.1; NC_011296.1.
DR   RefSeq; YP_002249870.1; NC_011296.1.
DR   AlphaFoldDB; B5YIZ6; -.
DR   SMR; B5YIZ6; -.
DR   STRING; 289376.THEYE_A2083; -.
DR   EnsemblBacteria; ACI21459; ACI21459; THEYE_A2083.
DR   KEGG; tye:THEYE_A2083; -.
DR   PATRIC; fig|289376.4.peg.2031; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_0; -.
DR   InParanoid; B5YIZ6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000718; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..544
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096697"
SQ   SEQUENCE   544 AA;  62436 MW;  AEFFF3EE031FA708 CRC64;
     MNRIKILPET IVGKISAGEV VERPASVVKE LIENSIDAGA NSISVYIKEF GIAEIKVIDD
     GEGIPSDDVI LAFQRHATSK IKDEKDLQRI SSLGFRGEAL YSIANVSKLK IITQYKDEDT
     GTEVYLTGGN LVSQKPVVTK GTTVEIRDLF FNTPVRRKFL KSSYTEKAHI IETVQNYCLA
     YPEISFSLFI DREEVLNIPQ VKTLYDRISQ VFGLEFTEKL KFKTISKDNY KIELFLGGEE
     LLRKSKGRQL IFVNRRPVKD FSIVNTIYKA FHINENHPQF FIFINLPPED VDFNVHPAKK
     EVRFREPQII HQLIFRMSEY QVKSSMIAEE TNQWKVNADL SSISQISAFY TESIFNKEEI
     FHFFSIGDAI VVIQRVDGIV FLDFHAAHER VNFEKILNKM SEQIVKLTFP HVINLNPQDY
     VLIKENLHIL NELGIEAEDF GENSIVIRAL PEIIKYIDIA GMIENIALTL KEGTSTPDFI
     EIKRKIAATI ACHSSLRANE KINHFEIKAL LQELERTSDP EHCPHGRPVR KFISLDEIKK
     WFLR