ID   MUTL_THIDA              Reviewed;         598 AA.
AC   Q3SIQ5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Tbd_1517;
OS   Thiobacillus denitrificans (strain ATCC 25259).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Thiobacillaceae; Thiobacillus.
OX   NCBI_TaxID=292415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25259;
RX   PubMed=16452431; DOI=10.1128/jb.188.4.1473-1488.2006;
RA   Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA   Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT   "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT   anaerobic bacterium Thiobacillus denitrificans.";
RL   J. Bacteriol. 188:1473-1488(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000116; AAZ97470.1; -; Genomic_DNA.
DR   RefSeq; WP_011312029.1; NC_007404.1.
DR   AlphaFoldDB; Q3SIQ5; -.
DR   SMR; Q3SIQ5; -.
DR   STRING; 292415.Tbd_1517; -.
DR   PRIDE; Q3SIQ5; -.
DR   EnsemblBacteria; AAZ97470; AAZ97470; Tbd_1517.
DR   KEGG; tbd:Tbd_1517; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_4; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000008291; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..598
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000071512"
SQ   SEQUENCE   598 AA;  64620 MW;  D75CEEF4DA690DC4 CRC64;
     MSIQVLSDVL ISQIAAGEVV ERPAAALKEI LENSLDAGAT AIDVELEQGG VKRIRVSDDG
     VGIPRDELAL ALTRHATSKI ATLADLEQVA SLGFRGEALA SIASVARVRL TSRHAGSDHA
     WTIHVDGGPL QPSSPAARSG GTTIDIEDMF FNTPARRKFL KTEATEYAHC AETVRRLALA
     WPQVAFTLVH NGRAQLRLKA EAAAARVRHV LGEVFEQHAI AVDAAAGALR LSGWVVRPVA
     ATASRDAQHV FVNGRYVRDK LIVHALREAY RDVLHHQLNP AYCLFVELPP EHVDVNVHPA
     KTEIRFRDSR GVHQFLYHAV ERLLAAPVAP AAPPSGPDAR PPTFLQPRQA AMSLQVEEAM
     AFYAPFAAMA PGEGDEARHV PQASAAGLAG RAGPPRAFAS DSSAVPPLGY ALGQLHGVYV
     LAQNAHGLVL VDMHAAHERV VYEKLKTALD RRAVPAQALL IPVALTADPR EVAEIAPHLD
     QLREIGFELS ITSPNSVAVR AVPSLLKNAD PVELTRAILA EIAEFGVARL LAERRNELLA
     TLACHGAVRA HRTLSVPEMN ALLREMEATE RAGQCNHGRP TWFQLRLDEL DAMFMRGR