ID   MUTL_TOLAT              Reviewed;         594 AA.
AC   C4L9N1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Tola_2387;
OS   Tolumonas auensis (strain DSM 9187 / TA4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Tolumonas.
OX   NCBI_TaxID=595494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9187 / TA4;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Spring S.,
RA   Beller H.;
RT   "Complete sequence of Tolumonas auensis DSM 9187.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001616; ACQ93984.1; -; Genomic_DNA.
DR   RefSeq; WP_015879452.1; NC_012691.1.
DR   AlphaFoldDB; C4L9N1; -.
DR   SMR; C4L9N1; -.
DR   STRING; 595494.Tola_2387; -.
DR   EnsemblBacteria; ACQ93984; ACQ93984; Tola_2387.
DR   KEGG; tau:Tola_2387; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000009073; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..594
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000203399"
SQ   SEQUENCE   594 AA;  66518 MW;  DA8E21BAA7B3A487 CRC64;
     MPIQILPPIL ANQIAAGEVV ERPASVIKEL VENSLDAGAN RIDVELEKGG CQLIRVRDNG
     GGICGTELAL ALARHATSKV ATLDDLEHIA SLGFRGEALA SISSVSRLTL TSRTAGQHEA
     WQAYAEGREM AVTVKPAAHP VGTTVEVLDL FFNTPARRRF LRSEKTEFAH IDELLRRLAL
     SRFDVAINLK HNGKLLRQYR PAQTESQQEQ RVVQACGAEF MQAALRIDSE HLGLHLYGWL
     APQPLTAINE VQYCYVNGRM IRDKLLNHAI RQAYSECTGT SFQPAYILYL ELDPHQVDVN
     VHPSKHEVRF HESRQVHDFI VQVIRQALQT AYSENAPDAV FSGIEDAAPD YPVSPLKNRA
     TGQHQYSAPT GGYSSPSGSQ LRSYGQLLTS ELPSIPVSRE AGSVAAPDNS DWPVLRLIQQ
     RYLLSAQDDT LYLSDLVAIQ SLQWLTQCNA SFNEGLIAQP LLIPQRLDIA RPHEWLAEYG
     IWLQKLGLRY NTHKNKQIII QAVPALLRQT DMASTIPAML SLLERYPVAL SHQEWHSFIA
     TWLKLPGLIP HHYSMDSARS LWLWLQQNVA DWQNNTQLMR SVDLTNILEV FSRD