ID   MUTL_TRIV2              Reviewed;         563 AA.
AC   Q3MEV6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Ava_0856;
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937;
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000117; ABA20480.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3MEV6; -.
DR   SMR; Q3MEV6; -.
DR   STRING; 240292.Ava_0856; -.
DR   EnsemblBacteria; ABA20480; ABA20480; Ava_0856.
DR   KEGG; ava:Ava_0856; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_1_3; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..563
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096627"
SQ   SEQUENCE   563 AA;  63214 MW;  523DDAA64A71BB6A CRC64;
     MASTIQALPQ EVVYLITAGE VIDSFAAVVR ELVENSLDAG ANRIVVYLWP QQWRVRVADN
     GCGMNLDDLQ QAASAHSTSK IRSSADLWKI HSLGFRGEAL HSLTTLADVE IISRAPENVG
     WRVVYGDNGE ATQVEATAIA PGTVVTVSNL FASCAARRQG LPTTAQQMKA VQATIQQIAL
     CHPQTTWQVW QNDRIWFTIS PAATAGQLIP QFLPQLRPGD LQEIKLEIPN PENPQLSTNN
     KANATTLSLV VGLPDRCHRH RPDWVRVAIN GRMIKSPELE QTILAAFHRT LPRDRYPLCF
     LHLLISPDQI NWNRNPAKTE IYLHDLSYWQ EQVTQAINQT LRISAANIKE SVQTTRVSQL
     LKAAEEKGNY NFNPQNANPA DNTQHYLKAV AQVSNTYIVA EHSGGMWLVE QHIAHERVLY
     EQLCDNWRLI PVEPPIILYQ LSPAQVAQLQ RIGLDIDIFG EQLWAVRNLP AMLQQREDCA
     EAILELSWGG DLQTAQVAVA CRSAIRNGTP MSLPEMQKLL DDWQRTRNPR TCPHGRPIYL
     SLDESSLSRF FRRHWVIGKS HGI