ID   MUTL_VIBPA              Reviewed;         669 AA.
AC   Q87L05;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VP2819;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BA000031; BAC61082.1; -; Genomic_DNA.
DR   RefSeq; NP_799198.1; NC_004603.1.
DR   RefSeq; WP_005480064.1; NC_004603.1.
DR   AlphaFoldDB; Q87L05; -.
DR   SMR; Q87L05; -.
DR   STRING; 223926.28807829; -.
DR   EnsemblBacteria; BAC61082; BAC61082; BAC61082.
DR   GeneID; 1190369; -.
DR   KEGG; vpa:VP2819; -.
DR   PATRIC; fig|223926.6.peg.2710; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; ATQEQAW; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..669
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177991"
FT   REGION          343..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   669 AA;  74919 MW;  5603DFE6D18D2CCD CRC64;
     MTIKILPARL ANQIAAGEVV ERPASVIKEL VENSLDSGAT RIDIDIEKGG AKLIRVRDNG
     KGIAKDELGL ALSRHATSKI HTLDDLEAIM SLGFRGEALA SISSVSRLTL TSRPAAQEEA
     WSAYSEGRDM QVKLQPAAHP IGTTVEVLDL FFNTPARRKF LRTEKTEFAH IDELLKRIAL
     SRFDVSINVR HNGKVIRQYR AAKNQLQTEK RIAAVCGNAF VRNMLRIELE HQGLKLHGWI
     TTPDGARQQS DLQYCYVNGR MMRDKLINHA IRQSYEMSLK PDQFAAYVLF IELDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQALADALA QSSVIDKPQV NESAFHRAEP EERESQPETT
     PQYSPQSVST TVPERVYQAI DKTPTYPGRT DYEIKPRDRA PSDSSVREAR IADSFKRTDW
     IESKLAPKPN VGKERHAEPA PSKREVHAYH ELLKTPDFES QQAEQPTSIE SVREVSLPQV
     TALGKALVVV DEQFVLMSSD SGVALVSLPR SEFYRTKGQL TPSEGALKAQ PLLVPLSMKL
     DTDLVRLAQD YQQDFAQLGI QLKARNDKAL MVMGVPAPLR QQNLQNLVPD LLSYAQTWMK
     GEKASTQMLP ALIDWLAVQV TTVKSHYTLS EAIQIIAELE QLRHGQLPLD DKTFVSAVDF
     SATIAKLKP