ID   MUTL_VIBVY              Reviewed;         664 AA.
AC   Q7MH01;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=VV3073;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; BA000037; BAC95837.1; -; Genomic_DNA.
DR   RefSeq; WP_011151329.1; NC_005139.1.
DR   AlphaFoldDB; Q7MH01; -.
DR   SMR; Q7MH01; -.
DR   STRING; 672.VV93_v1c28010; -.
DR   EnsemblBacteria; BAC95837; BAC95837; BAC95837.
DR   KEGG; vvy:VV3073; -.
DR   PATRIC; fig|196600.6.peg.3050; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OMA; ATQEQAW; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..664
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_0000177993"
FT   REGION          382..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..441
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   664 AA;  74025 MW;  65881981349268B7 CRC64;
     MTIRILPARL ANQIAAGEVV ERPASVVKEL VENSLDSGAT KIDIDIEKGG AKLIRIRDNG
     SGIVKDELGL ALSRHATSKI HTLDDLEAIM SLGFRGEALA SISSVSRLTL TSRPATQEQA
     WSAYTEGRDM QVKLQPTAHP IGTTVEVVDL FFNTPARRKF LRTEKTEFAH IDELLKRIAL
     SRFDVSITLR HNGKVIRQYR AAHNDLQAEK RLATVCGQAF VRCMLKIELE HQGLKLHGWI
     TTPEGARQQS DLQYCYVNGR MMRDKLINHA IRQSYETSLK PEQFAAYVLF IELDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQALASALA QSDSIEQPQI NESAFHYQAE PEVAPLGSFP
     AESNEVPQAV YHAIEKAPAY PRKAGQEQQL QPVAPLESSF SSEQGREVAP APHNERNAWM
     ESRSPARHTT SSNQSERYGE PAPSKQQVKA YAELLHTPDF PSQNVECHPS PSIASPVQEL
     GKAVSVVAQR YLLTTTKAGC QLISLARAEF YRILGQLNGD KAPLKSQPLL VPLSLKLEKG
     LVHAAQEHQD RFARMGILFK MRNEKALMVM GVPAPLRQQN LQLLIPDLLS YAASQAQKEE
     QAKNDTAMAQ WLALRVAKVK SHYTLSEAIQ IISELEQLWQ EKLPLQDAQL VTSVDFSATI
     AQLT