ID   MUTL_WOLWR              Reviewed;         605 AA.
AC   C0R515;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=WRi_013350;
OS   Wolbachia sp. subsp. Drosophila simulans (strain wRi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Wolbachieae; Wolbachia; unclassified Wolbachia.
OX   NCBI_TaxID=66084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=wRi;
RX   PubMed=19307581; DOI=10.1073/pnas.0810753106;
RA   Klasson L., Westberg J., Sapountzis P., Naeslund K., Lutnaes Y.,
RA   Darby A.C., Veneti Z., Chen L., Braig H.R., Garrett R., Bourtzis K.,
RA   Andersson S.G.;
RT   "The mosaic genome structure of the Wolbachia wRi strain infecting
RT   Drosophila simulans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5725-5730(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001391; ACN96007.1; -; Genomic_DNA.
DR   RefSeq; WP_007548532.1; NZ_MKIF01000114.1.
DR   AlphaFoldDB; C0R515; -.
DR   SMR; C0R515; -.
DR   STRING; 66084.WRi_013350; -.
DR   EnsemblBacteria; ACN96007; ACN96007; WRi_013350.
DR   KEGG; wri:WRi_013350; -.
DR   HOGENOM; CLU_004131_4_2_5; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001293; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..605
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000192191"
FT   REGION          334..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   605 AA;  68701 MW;  4B93B93A9CF3F0FF CRC64;
     MAIILLDTKT INRIAAGEVI ERPASVVKEL VENAIDAGSL EIEIKIESGG RNLIIVTDDG
     NGVEKNDLEL AFMRHATSKL SDSELIEIKH LGFRGEALPS IAAVSRIKLS SKAREASEAW
     SISYEGGEKI GEQTPYSLSQ GTHIEVRDLF FATPNRLKFL KTERAETQSI VDIVNNLAMI
     NYHIGFTLTS GNKKLLKYAK QTSLFHRLCE VEEEFQGSSL EINEEEDGIK LTGHICKPTV
     NRGKSTQIYT FVNGRPIKDN LLIGAVRYAY HDFIPSDRYP FAALHLEIPY DQVDVNVHPN
     KSEVRFQNKK LIYEIMTRGL IKALSRRIGT FPAHDQKMDS TLPDPFDKPD VQNERRPSPF
     ENQLIKEFAS PNEKAKGLSE QSKSFDYTGI QKFPAQAEAM VLEKKVLEQV DLIESHPLGF
     ARCQVYNTYI IAEVRDKLII VDQHAAHERL VYECLKQKSS IKRQKLLLPE TVEIKNQAGM
     EMIEIYKDKL FEMGFDIEIK SENKVIVKEI PAILGAIDVK EMLINIIDRL TEIEDTLPVE
     DKVNKILATI ACHGSIRAGR KMRLDEMNEL LRQMEKTPYS GQCNHGRPTY IEMKLSDIEK
     LFERR