ID   MUTL_XANC8              Reviewed;         624 AA.
AC   Q4UVP3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=XC_1817;
OS   Xanthomonas campestris pv. campestris (strain 8004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xanthomonas.
OX   NCBI_TaxID=314565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8004;
RX   PubMed=15899963; DOI=10.1101/gr.3378705;
RA   Qian W., Jia Y., Ren S.-X., He Y.-Q., Feng J.-X., Lu L.-F., Sun Q.,
RA   Ying G., Tang D.-J., Tang H., Wu W., Hao P., Wang L., Jiang B.-L., Zeng S.,
RA   Gu W.-Y., Lu G., Rong L., Tian Y., Yao Z., Fu G., Chen B., Fang R.,
RA   Qiang B., Chen Z., Zhao G.-P., Tang J.-L., He C.;
RT   "Comparative and functional genomic analyses of the pathogenicity of
RT   phytopathogen Xanthomonas campestris pv. campestris.";
RL   Genome Res. 15:757-767(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000050; AAY48880.1; -; Genomic_DNA.
DR   RefSeq; WP_011037442.1; NC_007086.1.
DR   AlphaFoldDB; Q4UVP3; -.
DR   SMR; Q4UVP3; -.
DR   EnsemblBacteria; AAY48880; AAY48880; XC_1817.
DR   KEGG; xcb:XC_1817; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   Proteomes; UP000000420; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..624
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010102"
SQ   SEQUENCE   624 AA;  67194 MW;  0BA1067CAA0799A0 CRC64;
     MAIRQLPEIL INQIAAGEVV ERPASVVKEL VENALDAGAT RVDIDLEEGG VRLIRIRDNG
     GGIAPEELPL AVSRHATSKI ASLDDLETVA TLGFRGEALP SIASVSRFTL ASRRPDAEHG
     SALQIEGGRL GEVMPRAHAP GTTVEVRELF FNVPARRKFL RAERTELGHI EEWLRSLALA
     RPDVELRVSH NGKPSRRYKP GDLYSDARLG ETLGEDFARQ ALRVDHSGAG LRLHGWVAQP
     HYSRASTDQQ YLYVNGRSVR DRSVAHAVKM AYGDVLFHGR QPAYVLFLEL DPARVDVNVH
     PAKHEVRFRE ARLIHDFVYR TLQDALAQTR AGALPADVGV GGAAALGIGA VAAQGGGSYV
     ADAGAGHPGA GSGSGYASWA PSQAPLGLRV DEARAAYAAL YAPAAGSALR DDGQPVLSGT
     GLPATAHDSG VPPLGYAVAQ LHGIYILAEN AEGLIVVDMH AAHERIGYER LKQAHDSIGL
     HAQPLLVPMT LAVGEREADT AEREADTLAS LGFEITRSGP QSLHVRSIPA LLANADPEAL
     LRDVLGDLRE HGQSRRIATA RDELLSTMAC HGAVRANRRL TVPEMNALLR DMEATERSGQ
     CNHGRPTWAR FTLGEIDRWF LRGR