ID   MUTL_XYLF2              Reviewed;         619 AA.
AC   B2I9E6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=XfasM23_2002;
OS   Xylella fastidiosa (strain M23).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405441;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M23;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP001011; ACB93401.1; -; Genomic_DNA.
DR   RefSeq; WP_012382761.1; NC_010577.1.
DR   AlphaFoldDB; B2I9E6; -.
DR   SMR; B2I9E6; -.
DR   EnsemblBacteria; ACB93401; ACB93401; XfasM23_2002.
DR   GeneID; 58017417; -.
DR   KEGG; xfn:XfasM23_2002; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   Proteomes; UP000001698; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..619
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096702"
SQ   SEQUENCE   619 AA;  67529 MW;  9B00F46CA2F2FCDD CRC64;
     MPIRQLPEIL INQIAAGEVV ERPASVVKEL VENAIDAGAT RVDIELEAAG VRLIRIRDNG
     HGMAAQELPL AVLRHATSKI ASLDDLEAVA TLGFRGEALP SIASVSRFTL MSRRATDEHG
     AVLQIEGGTL GEVIPHAHAP GTTVEVRELF YNVPARRKFL RAERTELGHI EEWARSLALA
     HPDLELRLSH NGKLSRRYKP GDWYSDVRLI EILGEDFAHQ ALRVDHSGAG LRLHGCIVQP
     HYSRLNADQQ YLYVNGRPVR DRSVAHAVKQ AYSDVLYQGR HPAYVLFLEL DPARVDVNVH
     PAKHEVRFRD ARLIHDFVYR TVQGTLAQTR AGTPPLAVGV GDVEGEGARP PGRHAVSFSG
     RRGGASHVLG SYSASTAPLM QGVPSVSVAD APAAYAALYA APPTQVMDAV PQMQTGLPLA
     AGAGDVPLLG YAIAQLHGIY ILAECADGLI VVDMHAAHER IGYERLKRAH DGIGLRTQPL
     LVPMTLMVAE READVAECEA ETLANLGFEV TRSGPGSLQV RSIPALLSQA EPEMLLRDVL
     SDLSEHGHTR RVAEARDTLL ATMACHGAVR AHRRLSISEM NALLRDMEAT ERSGQCNHGR
     PTWARFSLAE IDRWFLRGR