ID   MUTL_XYLFM              Reviewed;         621 AA.
AC   B0U5C6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   OrderedLocusNames=Xfasm12_2081;
OS   Xylella fastidiosa (strain M12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=405440;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M12;
RX   PubMed=20601474; DOI=10.1128/jb.00651-10;
RA   Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.;
RT   "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23)
RT   causing almond leaf scorch disease in California.";
RL   J. Bacteriol. 192:4534-4534(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000941; ACA12944.1; -; Genomic_DNA.
DR   RefSeq; WP_004084548.1; NC_010513.1.
DR   AlphaFoldDB; B0U5C6; -.
DR   SMR; B0U5C6; -.
DR   KEGG; xfm:Xfasm12_2081; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   OMA; AHERIMY; -.
DR   OrthoDB; 764332at2; -.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.1540.20; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 2.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..621
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000096703"
SQ   SEQUENCE   621 AA;  67674 MW;  A5F1109E819581EA CRC64;
     MPIRQLPEIL INQIAAGEVV ERPASVVKEL VENAIDAGAT RVDIELEAAG VRLIRIRDNG
     HGMAAQELPL AVLRHATSKI ASLDDLEAVA TLGFRGEALP SIASVSRFTL MSRRATDEHG
     AVLQIEGGTL GEVIPHAHAP GTTVEVRELF YNVPARRKFL RAERTELGHI EEWARSLALA
     HPDLELRLSH NGKLSRRYKP GDWYSDARLI EILGEDFAHQ ALRVDHSGAG LRLHGCIVQP
     HYSRLNADQQ YLYVNGRPVR DRSVAHAVKQ AYSDVLYQGR HPAYVLFLEL DPARVDVNVH
     PAKHEVRFRD ARLIHDFVYR TVQGTLAQTR AGTPPLAVGV GDVEGEGEGA RPPGRHAVSF
     SGRRGGASHV LGSYSTSTAP LMQGVPSVSV ADAPAAYAAL YAAPPTQVMD AVPQMQTGLP
     LAAGAGDVPP LGYAIAQLHG IYILAECADG LIVVDMHAAH ERIGYERLKR AHDGIGLRTQ
     PLLVPMTLMV AEREADVAEC EAETLASLGF EVTRSGPGSL QVRSIPALLS QAEPEMLLRD
     VLSDLSEHGH TRRVAEARDT LLATMACHGA VRAHRRLSIS EMNALLRDME ATERSGQCNH
     GRPTWARFSL AEIDRWFLRG R