MUTL_YERPG
ID MUTL_YERPG Reviewed; 635 AA.
AC A9QYN3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN OrderedLocusNames=YpAngola_A0701;
OS Yersinia pestis bv. Antiqua (strain Angola).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Angola;
RX PubMed=20061468; DOI=10.1128/jb.01518-09;
RA Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA Achtman M., Lindler L.E., Ravel J.;
RT "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT new insights into the evolution and pangenome of the plague bacterium.";
RL J. Bacteriol. 192:1685-1699(2010).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000901; ABX85002.1; -; Genomic_DNA.
DR RefSeq; WP_012229092.1; NZ_CP009935.1.
DR AlphaFoldDB; A9QYN3; -.
DR SMR; A9QYN3; -.
DR KEGG; ypg:YpAngola_A0701; -.
DR PATRIC; fig|349746.12.peg.1649; -.
DR OMA; ATQEQAW; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..635
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096705"
SQ SEQUENCE 635 AA; 70304 MW; 4C5CA8115551C810 CRC64;
MPIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
CGISKDDLAL ALARHATSKI SSLEDLEAIL SMGFRGEALA SISSVSRLIL TSRTAEQSEA
WQAYAEGRDM AVTIKPAAHP VGSTLEVLDL FYNTPARRKF MRTEKTEFGH IDEVVRRIAL
ARFDVAINLN HNGKLIRQYR AAPDPAQHER RLASICGPAF LQHALAIAWQ HGDLNIHGWV
ADPAASHTLS EMQYCYVNNR MMRDRLINHA IRQAYQDRLN DAQQPAYVLY LDIDPHQVDV
NVHPAKHEVR FHQARLVHDF IYQAVTAVLQ QTNAPILNIS EEGEVDAPRW QQENRVAAGT
NKYAQPEAAK SSAAEQAVAR ERSSARERAA LAYKEDHPYQ KQQGELYRQL LQPSAAAKPA
TSPAAIPASS VSSPSIPVQR ITQAEEPLHG DNYSFGRVLT VFPPCYALIE YQGGVALLSL
AVAERWLKQA QLSPPEEGLR PQPLLIPLKI TLDKNEIAAC QNHEKLLITM GIELSVEQGR
ATLRAVSLPL RQQNLQKLIP ELLGYLSQHE EISPDTLATW LARHLGSEHE VWNVSQAIQL
LTEVERLCPQ LVQSPPAGLL QPIDIKAALA TLTHE