MUTL_YERPY
ID MUTL_YERPY Reviewed; 635 AA.
AC B1JMP1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=YPK_3801;
OS Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=502800;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YPIII;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000950; ACA70068.1; -; Genomic_DNA.
DR RefSeq; WP_002209148.1; NZ_CP009792.1.
DR AlphaFoldDB; B1JMP1; -.
DR SMR; B1JMP1; -.
DR EnsemblBacteria; ACA70068; ACA70068; YPK_3801.
DR GeneID; 66843159; -.
DR KEGG; ypy:YPK_3801; -.
DR PATRIC; fig|502800.11.peg.149; -.
DR OMA; ATQEQAW; -.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1370.100; -; 1.
DR Gene3D; 3.30.1540.20; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR002099; DNA_mismatch_repair_N.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR038973; MutL/Mlh/Pms.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR PANTHER; PTHR10073; PTHR10073; 2.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF118116; SSF118116; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00585; mutl; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..635
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096706"
FT REGION 359..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 70288 MW; 301CA81150449D45 CRC64;
MPIQILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
CGISKDDLAL ALARHATSKI SSLEDLEAIL SMGFRGEALA SISSVSRLIL TSRTAEQSEA
WQAYAEGRDM AVTIKPAAHP VGSTLEVLDL FYNTPARRKF MRTEKTEFGH IDEVVRRIAL
ARFDVAINLN HNGKLIRQYR AAPDPAQHER RLASICGPAF LQHALAIAWQ HGDLNIHGWV
ADPAASHTLS EMQYCYVNNR MMRDRLINHA IRQAYQDRLN DAQQPAYVLY LDIDPHQVDV
NVHPAKHEVR FHQARLVHDF IYQAVTAVLQ QTNAPILNIS EEGEVDAPRW QQENRVAAGT
NKYAQPEAAK SSAAEQAVAR ERSSARERAA PAYKEDHPYQ KQQGELYRQL LQPSAAAKPA
TSPAAIPASS VSSPSIPVQR ITQAEEPLHG DNYSFGRVLT VFPPCYALIE YQGGVALLSL
AVAERWLKQA QLSPPEEGLR PQPLLIPLKI TLDKNEIAAC QNHEKLLITM GIELSVEQGR
ATLRAVSLPL RQQNLQKLIP ELLGYLSQHE EISPDTLATW LARHLGSEHE VWNVSQAIQL
LTEVERLCPQ LVQSPPAGLL QPIDIKAALA TLTHE