ID   MUTS1_HALMA             Reviewed;         921 AA.
AC   Q5UZG9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS 1 {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS1 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=rrnAC2532;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV47334.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY596297; AAV47334.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_049939015.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5UZG9; -.
DR   SMR; Q5UZG9; -.
DR   STRING; 272569.rrnAC2532; -.
DR   PRIDE; Q5UZG9; -.
DR   EnsemblBacteria; AAV47334; AAV47334; rrnAC2532.
DR   GeneID; 40153426; -.
DR   KEGG; hma:rrnAC2532; -.
DR   PATRIC; fig|272569.17.peg.3140; -.
DR   eggNOG; arCOG02896; Archaea.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..921
FT                   /note="DNA mismatch repair protein MutS 1"
FT                   /id="PRO_0000224422"
FT   REGION          837..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        865..884
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         619..626
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   921 AA;  99919 MW;  D7E32A431D90FB2C CRC64;
     MTEATGIVGE FLTLKEGTDA DLLAMQCGDF YEFFAEDAEI VADELDLKVS QKSSHGSSYP
     MAGVPVDDLT PYVSALVERG YRVAIADQHE TENGHAREIT RVVTPGTHLE TGDESAQYLA
     AVVREASRDS GDTYGIAATD VTTGQFQVTQ LDDADAGEAL TELYTFGPAE ILPGPELRND
     DEFLDRLRER TDAALTLHDS ASFEPGRASH TVREQFGSET VDSVGIGDQN VAVRAAGAVL
     SYVEDTGVGT LAAVTRLQAY GERDHVDLDA TTQRNLELTE TMQGDSSGSL FDTIDHTVTA
     AGGRLLQQWL QRPRRNRAEL QRRQSCVAAL SEAAMARERI RETLSDAYDL ERLAARATSG
     SADARDLRAV QETLALLGQV ADAVTETERL AESPLADALD GADREAADSL AAELDSALVA
     DPPGTVRQGG LFKRGHDDDL DEIIDEHEAA LEWLETLPDR EKERTGITHL SVDRNKTDGY
     YIQVGKSETD AVPEKYQHIK TLKNSKRYTT PELDEKERDV LRLEERRHDM EYEHFQRLRA
     RVAEHATLLQ DVGRTLAELD AFASLAVHAV ENDWARPAVV DGNELSIEAG RHPVVEQTTE
     FVPNDLYMDD DRQFLIVTGP NMSGKSTYMR QAALITLLAQ VGSFVPARSA TVGLVDGIFT
     RVGALDELAQ GRSTFMVEMQ ELSNILHSAT EESLVILDEV GRGTATFDGI SIAWAATEYI
     VNSIQSKTLF ATHYHELTAL GEELPTVENV HVAVDGEPRS AGSDGDVTFL RTVRDGPTDR
     SYGVHVADLA GVPEPVVDRS QAVLDRLRDD KAIEIRGSEQ NDGGTTQAVF DLDSGQFRDG
     AAQSGGAAAG STAEPVATDG DPEHAPGEAA AEGPKGDERA ASLDSETEAV LSELTELDVN
     ETPPVELMAK VQEWQAELDD E