ID   MUTS1_HALSA             Reviewed;         871 AA.
AC   Q9HSM2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutS 1;
GN   Name=mutS1; OrderedLocusNames=VNG_0163G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG18781.1; -; Genomic_DNA.
DR   PIR; A84177; A84177.
DR   RefSeq; WP_010902076.1; NC_002607.1.
DR   AlphaFoldDB; Q9HSM2; -.
DR   SMR; Q9HSM2; -.
DR   STRING; 64091.VNG_0163G; -.
DR   PaxDb; Q9HSM2; -.
DR   EnsemblBacteria; AAG18781; AAG18781; VNG_0163G.
DR   GeneID; 5953520; -.
DR   KEGG; hal:VNG_0163G; -.
DR   PATRIC; fig|64091.14.peg.117; -.
DR   HOGENOM; CLU_002472_4_1_2; -.
DR   InParanoid; Q9HSM2; -.
DR   OMA; MQCGDFY; -.
DR   OrthoDB; 1024at2157; -.
DR   PhylomeDB; Q9HSM2; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS 1"
FT                   /id="PRO_0000115175"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   871 AA;  92980 MW;  025E919E4E96D22E CRC64;
     MGIVDEFQAL KAETDADLLA MQVGDFYEFF AADARTVASV LDLQVSEKSN HGSSYPMAGV
     PVDDLTPYLA ALVERGYRVA VAEQSETDAG DIEREIERVV TPGTLLASTD ADPRYLAAVV
     REAGGDWGLA FVDVTTGQFR VTRGADRADA VTELYRFAPA EVLPGPALRG DDDFLGVLRE
     RTDATLTLHD AGAFDAGRAT HRVREQFGDG VIESLGVAAD GPVVRAAGAA VGYIAAADEG
     VLASVSRIQP FGGGDHVELD ATTQRNLELT ETMTGGSDGS LLATIDHTAS AAGGRRLAAW
     VTRPTRDRAE LDRRQAAVGA LADAALARDA LGDVLGEIYD LERLASRAAS GRADATDLLR
     VRDTLAALPD VADALTTTPE LAESPARDVL ARVDRAAAAD VRAELADALA DDPPKTLSEG
     GLLQAGYDEA LDELLAAHDE HRAWLDGLAD REKDRLGITH LQVDRNKTDG YYIQVGNSET
     DAVPDGEDGA YRRIKQLKNA TRYTMAELDS HEREVLRIEA ERAELERELF AALRERVGER
     AAVLQDVGRA LAEVDALVSL AEHAAANQWV RPELVAGDGL DIDAGRHPVV EQTTSFVPND
     ARFDASRRFQ VVTGPNMSGK STYMRQVAVI VLLAQVGSFV PADAARIGLV DGIYTRVGAL
     DELAGGRSTF MVEMEELSRI LHAATSDSLV VLDEVGRGTA TYDGISIAWA ATEYLHNEVR
     ATTLFATHYH ELTALADHLD AVVNVHVAAE ERDGAVTFLR TVRDGATDRS YGVHVAALAG
     VPEPVVDRAR GVLDRLREEN AVEAKGSAGE SVQAVFDVDS GGFVDDAGDD GEADDPEAAA
     VLDELRTVEL AETSPVELLG TVQAWQDRLE D