ID   MUTS2_ALKHC             Reviewed;         785 AA.
AC   Q9K8A0;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=BH3106;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; BA000004; BAB06825.1; -; Genomic_DNA.
DR   PIR; B84038; B84038.
DR   RefSeq; WP_010899250.1; NC_002570.2.
DR   AlphaFoldDB; Q9K8A0; -.
DR   SMR; Q9K8A0; -.
DR   STRING; 272558.10175728; -.
DR   PRIDE; Q9K8A0; -.
DR   EnsemblBacteria; BAB06825; BAB06825; BAB06825.
DR   KEGG; bha:BH3106; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   CDD; cd03280; ABC_MutS2; 1.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..785
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_0000115216"
FT   DOMAIN          710..785
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   REGION          764..785
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         335..342
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   785 AA;  87427 MW;  DBED779F2F4671C6 CRC64;
     MERVLRVLEY EKMKKQLLEH VSSSLGRKKV EQLTPSTDFN KVKLWQAQTQ EGANMLRLKG
     HVPLGGIFDI KPHLKRAKIG GLLHASELLE VASTIYGGRQ LKKFIETMIE EEEADLPLLG
     EFARQIVPLT DLERAIKQCI DDNGHVLDSA SPTLRTLRHQ IRSFEANVRS KLEGITRSSN
     TAKMLSDAIV TIRNDRYVIP VKQEYRGAFG GIVHDQSASG ATLFVEPQAV VEINNQLREA
     KAKEQREIER ILSELSMQVS EHVDDLFVNV DVLAELDFIM ARAHYGKAIR ATQPILNNRG
     YLLIKQGRHP LIPDDEIVPI DIELGHSYSS LVITGPNTGG KTVTLKTIGL LTLMAQSGLH
     VPAEEESELA VFKHVFADIG DEQSIEQSLS TFSSHMTNIV DILGKVDHES LVLFDELGAG
     TDPTEGAALA IAILDDVYRR GARIVATTHY SELKGYAYNR EGVMNASVEF DVETLSPTYR
     LLIGVPGRSN AFAISKRLGL EEKIIEQAKA HIDEDASQVE SMIASLEQSQ KSAESDWEEA
     EKALQEAEQL RLDLQKKLDD LEKEKERILA EAEQQAEQAV KDAKEEAEVI ISELRDLQKQ
     GVSVKEHQII DAKKHLEEAA PKLTKQQKKV KRTAEKKREF KPGDEVKVLS FGQKGHIVEK
     VSEAEYQVQM GIMKMKVEAS DLQLIDRPQP VETKPLATIR GSDHHVKPEL DLRGERYEEA
     MLKVEKYLDD ALLAGYASVS IIHGKGTGAL RKGVKDLLKR HPHVKSARDG GANEGGLGNT
     VVELR