ID   MUTS2_ANADF             Reviewed;         805 AA.
AC   A7HAB8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
GN   OrderedLocusNames=Anae109_1457;
OS   Anaeromyxobacter sp. (strain Fw109-5).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter;
OC   unclassified Anaeromyxobacter.
OX   NCBI_TaxID=404589;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fw109-5;
RX   PubMed=25614562; DOI=10.1128/genomea.01449-14;
RA   Hwang C., Copeland A., Lucas S., Lapidus A., Barry K., Glavina Del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D.C.,
RA   Detter J.C., Han C.S., Schmutz J., Larimer F.W., Land M.L., Hauser L.J.,
RA   Kyrpides N., Lykidis A., Richardson P., Belieav A., Sanford R.A.,
RA   Loeffler F.E., Fields M.W.;
RT   "Complete genome sequence of Anaeromyxobacter sp. Fw109-5, an anaerobic,
RT   metal-reducing bacterium isolated from a contaminated subsurface
RT   environment.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; CP000769; ABS25664.1; -; Genomic_DNA.
DR   RefSeq; WP_011985770.1; NC_009675.1.
DR   AlphaFoldDB; A7HAB8; -.
DR   SMR; A7HAB8; -.
DR   STRING; 404589.Anae109_1457; -.
DR   EnsemblBacteria; ABS25664; ABS25664; Anae109_1457.
DR   KEGG; afw:Anae109_1457; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_0_7; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000006382; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..805
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000093340"
FT   DOMAIN          729..804
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   REGION          705..724
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         344..351
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   805 AA;  84747 MW;  F008351F931A98DD CRC64;
     MTDRTQRELG WPEILNALAA RCRLPAGRNR ALALPFQPTA EAAREALALV GEARRLSELA
     LALPLGGVGD VEGHLERASK GGVLEPLALR ECAALARAAA RTRGLLEARA SETPRLWALA
     EPLSPSAALA DRIERAIEPS GAISDRASAE LAQARERSRG LHRALKAQVE TLLADADMQR
     HLRDTYFTIR NERYVLPVLA SARRAVPGIV HNASQSGQTL FVEPDSMVEL GNELSIANAV
     AAEEEQRILR ELTGALMADS GALARDLGIL AALDVLEGSA LLASDLDAHA PEVLSPFDGL
     RVGGAGAGFE LLSLRHPLLV LQGKKVVPSH VRLDAPARAL IVSGPNGGGK TVAITAVGLS
     ALMLRAGLPV AAAEGSRLPF FLEVKAAVDE RGDLAKDLST FTAHLAAVKE MLAGAVPGSL
     ILVDEIAADT DPREGAALAA AILESLVERG AAVLVTTHLD ELKALALTDP RYANARVGFD
     AERLAPTYQL HLGSPGSSSA IEVAARVGLP APLVERARAA LTGHGGALGQ ALRALDDERA
     RLAEERRAAE SARDAARKAE ERARAAEEVA RRAQREAAAR MGEALADELE AARAEVAELL
     AGLQARPTVK AATDAARQLD AWRATVAQAA KATQARADAG AEALPGGEVR PGVRVRIVSL
     GQEGEVVEVD GKDALVRAGP LKVRRPVADL VPLLGKAKDA AKLGRSRSEK LQAASEARPS
     APPGLERRLD VRGLRVEELL REVERFLDRL YSDGEADCLI LHGHGTGALK QALRDHLSAS
     PYVGAFRAGD RHEGGDAVTV VSLRR