MUTS2_AQUAE
ID MUTS2_AQUAE Reviewed; 762 AA.
AC O67287;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; Synonyms=mutSB;
GN OrderedLocusNames=aq_1242;
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR EMBL; AE000657; AAC07247.1; -; Genomic_DNA.
DR PIR; D70407; D70407.
DR RefSeq; NP_213851.1; NC_000918.1.
DR RefSeq; WP_010880789.1; NC_000918.1.
DR AlphaFoldDB; O67287; -.
DR SMR; O67287; -.
DR STRING; 224324.aq_1242; -.
DR EnsemblBacteria; AAC07247; AAC07247; aq_1242.
DR KEGG; aae:aq_1242; -.
DR PATRIC; fig|224324.8.peg.968; -.
DR eggNOG; COG1193; Bacteria.
DR HOGENOM; CLU_011252_2_1_0; -.
DR InParanoid; O67287; -.
DR OMA; IHAIIND; -.
DR OrthoDB; 256392at2; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..762
FT /note="Endonuclease MutS2"
FT /id="PRO_0000115215"
FT DOMAIN 682..757
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT BINDING 329..336
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 762 AA; 87538 MW; 3A7D977DC2EB01BC CRC64;
MREKDLIKLE FDKVKEVLAS YAHSPATKEK IQNLKPYTNK EKVKEEIELS KAFFDIAENV
RLFEFEDIRE LLKKAKLQGA ILGVEDILKI LNVINLTKEI RRVLSSHVQR LEPLRKVYKK
LYTFSPLENL IIGSIDPRGF VKDEASEELL RVRKSIRAVE EEIKKRLDNL INRPDSAKFL
SDRIVTIRNG RYVIPVKTSH VKKIFGIVHG TSSSGYTTYV EPQFVIHLNN KLTELKQKEE
EEVRKVLQRI TEYIGDYAKE LLESFEACVE VDFQQCKYRF SKLVEGSFPD FGEWVELYEA
RHPVLVLVKE DVVPVGILLK EKKGLILTGP NTGGKTVALK TLGLSVLMFQ SAIPVPASPN
SKLPLFEKVF TDIGDEQSIE QNLSTFSAHV KNMAEFLPKS DENTLVLIDE LGAGTDPIEG
SALGIGILEY LKKKKAWVFV TTHHTPIKLY STNSDYYTPA SVLFDRETLK PLYKIAYNTV
GESMAFYIAQ KYGIPSEVIE IAKRHVGEFG EQYIKAMEKL SDYVKKYEEE FRKLEELRKE
LQKEKEEVEK LRKEYEEAKR KGWKEAYKEA REYLRKLVQE SEEIFKKAKE KKEIKEFVSK
KREEIENLAP QKPQKLEVGD LVEFMGKKGK VLEVKGNKAL VLVDHLRMWL DTRELQKVGK
AEPQKETKVT VQTPVMEKRD TLNLIGKDVE TAVRELEKFI EEAYSAGYKV VKVIHGIGSG
KLKSAVREAL SKNEKVKFFR DAYPKEGGSG VTVVYLEYGE ET