MUTS2_BACAN
ID MUTS2_BACAN Reviewed; 786 AA.
AC Q81L40; Q6HSJ4; Q6KLT9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
GN OrderedLocusNames=BA_4794, GBAA_4794, BAS4447;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR EMBL; AE016879; AAP28483.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT33915.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT56745.1; -; Genomic_DNA.
DR RefSeq; NP_846997.1; NC_003997.3.
DR RefSeq; WP_000893730.1; NZ_WXXJ01000026.1.
DR RefSeq; YP_030694.1; NC_005945.1.
DR AlphaFoldDB; Q81L40; -.
DR SMR; Q81L40; -.
DR IntAct; Q81L40; 2.
DR STRING; 260799.BAS4447; -.
DR EnsemblBacteria; AAP28483; AAP28483; BA_4794.
DR EnsemblBacteria; AAT33915; AAT33915; GBAA_4794.
DR GeneID; 45024423; -.
DR KEGG; ban:BA_4794; -.
DR KEGG; bar:GBAA_4794; -.
DR KEGG; bat:BAS4447; -.
DR PATRIC; fig|198094.11.peg.4755; -.
DR eggNOG; COG1193; Bacteria.
DR HOGENOM; CLU_011252_2_1_9; -.
DR OMA; IHAIIND; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..786
FT /note="Endonuclease MutS2"
FT /id="PRO_1000075467"
FT DOMAIN 711..786
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT BINDING 335..342
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 786 AA; 88189 MW; 6FA57DAA9F64F320 CRC64;
MLERTLRVLE YNKVKEQLLE HTASSLGRDK VKHLVPSTDF EEIVEMQDTT DEAAKVIRLK
GSAPLGGITD IRSNVKRAKI GSMLSPNELL DIANTMYGSR NMKRFIEDMV DNGVELPILE
THVAQIVSLY DLEKKITNCI GDGGEVVDSA SDKLRGIRTQ IRTAESRIRE KLENMTRSSN
AQKMLSDSIV TIRNERYVIP VKQEYRGVYG GIVHDQSASG QTLFIEPQVI VELNNALQEA
RVKEKQEIER ILLMLTEEVA VEADIVLSNV EVVANLDFIF AKAFYAKRIK ATKPIVNNER
YMDLRQARHP LIDPEVIVPN NIMLGKDFTT IVITGPNTGG KTVTLKTVGI CVLMAQSGLH
IPVMDESEIC VFKNIFADIG DEQSIEQSLS TFSSHMVNIV DILEKADFES LVLFDELGAG
TDPQEGAALA ISILDEVCNR GARVVATTHY PELKAYGYNR EQVINASVEF DVNTLSPTHK
LLIGVPGRSN AFEISKRLGL SNRVIDQARN HISTDTNKIE NMIAKLEESQ KNAERDWNEA
EALRKQSEKL HRELQRQIIE FNEERDERLL KAQKEGEEKV EAAKKEAEGI IQELRQLRKA
QLANVKDHEL IEAKSRLEGA APELVKKQKV NVKNTAPKQQ LRAGDEVKVL TFGQKGQLLE
KVSDTEWSVQ IGILKMKVKE SNMEYINTPK QTEKKAVATV KGRDYHVSLE LDLRGERFEN
AMARVEKYLD DAQLASYPRV SIIHGKGTGA LRQGVQDYLK KHRGVKTFRY GDMGEGGLGV
TVVELK