MUTS2_BACMK
ID MUTS2_BACMK Reviewed; 786 AA.
AC A9VJL2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
GN OrderedLocusNames=BcerKBAB4_4380;
OS Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=315730;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KBAB4;
RX PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "Extending the Bacillus cereus group genomics to putative food-borne
RT pathogens of different toxicity.";
RL Chem. Biol. Interact. 171:236-249(2008).
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000903; ABY45539.1; -; Genomic_DNA.
DR RefSeq; WP_012261787.1; NC_010184.1.
DR AlphaFoldDB; A9VJL2; -.
DR SMR; A9VJL2; -.
DR STRING; 315730.BcerKBAB4_4380; -.
DR EnsemblBacteria; ABY45539; ABY45539; BcerKBAB4_4380.
DR KEGG; bwe:BcerKBAB4_4380; -.
DR eggNOG; COG1193; Bacteria.
DR HOGENOM; CLU_011252_2_1_9; -.
DR OMA; IHAIIND; -.
DR Proteomes; UP000002154; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding.
FT CHAIN 1..786
FT /note="Endonuclease MutS2"
FT /id="PRO_1000093341"
FT DOMAIN 711..786
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT REGION 529..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 335..342
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 786 AA; 88458 MW; E132EF35F8D36489 CRC64;
MLERTLRVLE YNKVKEQLLE HTASSLGRDK VKNLVPSTDF EEIVELQETT DEAAKVIRLK
GHVPLGGISD IRANIKRAKI GSMLSPHELI EIASTMYGSR QMKRFIDDMI DNGVELPILE
THVAQIVSLY DLEKKITNCI GDGGEVVDSA SDKLRGIRNQ IRTAESRIRE KLENMTRSSN
AQKMLSDAIV TIRNERYVIP VKQEYRGVYG GIVHDQSASG QTLFIEPQVI VELNNALQEA
RVKEKQEVER ILMMLTEEVA VEADIVLSNV EVVANLDFIF AKALYAKRIK ATKPIVNNER
YMDLKQARHP LIDPEIIVPN NIMLGKDFTT IVITGPNTGG KTVTLKTVGI CVLMAQSGLH
IPVMDESEIC VFKNIFADIG DEQSIEQNLS TFSSHMVNIV DILEKADFES LVLFDELGAG
TDPQEGAALA ISILDEVCNR GARVVATTHY PELKAYGYNR EQVINASVEF DVNTLSPTYK
LLIGVPGRSN AFEISKRLGL SDRVIDRARN HISTDTNKIE NMIAKLEESQ KNAERERKEA
EEHRKQSEKL HRELQRQIIE FNDERDEKLL KAQKEGEEKV EAAKQEAEGI IQELRQLRKA
QLINVKDHEL IEAKSRLEGA APELVKKQKV NVKNTAPKQQ LRSGDEVKVL TFGQKGQLLE
KVSDTEWSVQ IGILKMKVKE SNMEYINTPK QTEKKAVASV KGRDYHVSLE LDLRGERYED
AMMRVEKYLD DAQLASYPRV SIIHGKGTGA LRQGVQDYLK KHRGVKTYRY GDMGEGGLGV
TVVELK