ID   MUTS2_CALS4             Reviewed;         790 AA.
AC   Q8R9D0;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=TTE1685;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; AE008691; AAM24886.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8R9D0; -.
DR   SMR; Q8R9D0; -.
DR   STRING; 273068.TTE1685; -.
DR   EnsemblBacteria; AAM24886; AAM24886; TTE1685.
DR   KEGG; tte:TTE1685; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   CDD; cd03280; ABC_MutS2; 1.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..790
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_0000115239"
FT   DOMAIN          713..788
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         334..341
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   790 AA;  90015 MW;  710FF5734ABA132D CRC64;
     MKGMREKTLK SLEFDKIVKL IANECDSELG REKVFDIEIK KDLKAIEFEL DLLNEAVKFI
     YSYGDISFSF QDIREHVKKA QIDYILYNRE LLGIKNFLSL VEEVKAHFKS LYDREDFLLL
     KEFDKRLVPL KSLKEKIENT VISEDEISDE ASPVLKAIRR QKASINEKIK STLNSIISTR
     QKELQEPIIT MRQGRYVVPV KQEYRNVFKG IIHDQSSTGA TLFIEPIQVV DLNNELRELE
     LKEQKEIERI LFELSQEVKK NAEAIFKDVE VVSELDFLFA KARYSIKIKA SRPELNTSGY
     VNLKKARHPL IDPEKVVPID IHIGREFTTL VITGPNTGGK TVTLKTVGLL TLMAMAGINI
     PAEEKSQISI FEDVFVDIGD EQSIEQSLST FSSHMTNIVS ILKKVNKNSL VLLDELGAGT
     DPLEGSALAM SILDFLHRTG CRTIATTHYS ELKQYALKTK GVENASVEFD VETLRPTYRL
     IIGIPGRSNA FEISRRLGLS EEIIENAKSY MSGEAIRFED VIKDVEEKRK DLENAYQEVE
     RLKKEVEVLK EELEKEKRKL ESQKDKILKE AKEKAREIIK EAKQTAEEVI KRIKEAEEKE
     KNKDRAIQEI REKIKKNLEE LEEEVLKPKE FSYGKIPDSL KAGQTVYIVP LDQNGIVLSP
     PDASGNVEVQ AGILKMTVHI SNLRVKEEQE QEEVKKGYSR FINEKAKSIS PSLDVRGMTL
     DDALLEVEKY IDDAYLAGLN QVTIIHGRGT GVLRTGIAKF LRNSKYVKSF RLGRYGEGGD
     GVTIVELHSR