MUTS2_CLOD6
ID MUTS2_CLOD6 Reviewed; 792 AA.
AC Q189Q3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
GN OrderedLocusNames=CD630_07090;
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630;
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM180355; CAJ67542.1; -; Genomic_DNA.
DR RefSeq; WP_011860930.1; NZ_CP010905.2.
DR RefSeq; YP_001087185.1; NC_009089.1.
DR AlphaFoldDB; Q189Q3; -.
DR SMR; Q189Q3; -.
DR STRING; 272563.CD630_07090; -.
DR EnsemblBacteria; CAJ67542; CAJ67542; CD630_07090.
DR KEGG; cdf:CD630_07090; -.
DR KEGG; pdc:CDIF630_00824; -.
DR PATRIC; fig|272563.120.peg.729; -.
DR eggNOG; COG1193; Bacteria.
DR OMA; IHAIIND; -.
DR PhylomeDB; Q189Q3; -.
DR BioCyc; PDIF272563:G12WB-819-MON; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..792
FT /note="Endonuclease MutS2"
FT /id="PRO_1000093350"
FT DOMAIN 717..792
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT BINDING 335..342
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 792 AA; 88204 MW; 48496FA9C55C2D1D CRC64;
MNEKSLRVLE YNKIIDLLKK KASSSLGLKY IENLVPNTDF VEVKSMLEET SEAQSIIIKR
GSVGLEGIHD IEDKVKRAYI GASLDPGSLI MIADTLRVAR RLRNSLSSSD EEDFNYPIIQ
SLSNSLYVYK DIEDQIYNAI ISEVEISDNA SSILRDIRRR IAQKNQSIRS KLNSIISSTT
YQKYLQDAII SLRGDRFVVP VKSEYRSQVA GIVHDQSSSG ATLFIEPMTI VEMNNELRQL
KLGEQEEIER ILSELSAMVG EVSEDLISNQ EILGRLDFAF SKGKLSIQMR GIEPTLNEDK
YLNIKNGRHP LLDKKKVVAN TIYLGRDFHT LVITGPNTGG KTVTIKTVGL FALMTQSGLH
IPADYGSSMC VYDNVFADIG DEQSIEQSLS TFSSHMTNIV SILQNVTADS LVIFDELGAG
TDPVEGAALA IAVLEDINSV GAKCIATTHY SELKNYALTK SGVENAAVEF DIETLSPTYK
LLIGVPGKSN AFEISRKLGL SDYVISRAKE YINTENIALE DVLQNVEKNR IKAVEDREEA
ERLKEEIEKL KVEYDEKLEK LVSQRDKMIE KAKSEAFSII RQAKEEVDII IKELRSLEQE
RASKEKNRKI EELRKELTSS MGSLQPTVKS MIVPKVSNKE IKDLKPGEEV KVITLNQNGS
VVSVDKKRKE AVVQIGIMKM TLPFKSLQKT RKDVSTNVTK STRNIIRSKS GSVKNEVDLR
GLNLEEAIME VEKYLDDAYV AGLESVTVIH GIGTGVLKAG LQDILRRNRH VKSQRGGQYG
EGGAGVTIVK LK