ID   MUTS2_CLONN             Reviewed;         785 AA.
AC   A0PZP4;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
GN   OrderedLocusNames=NT01CX_1773;
OS   Clostridium novyi (strain NT).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=386415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NT;
RX   PubMed=17115055; DOI=10.1038/nbt1256;
RA   Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X.,
RA   Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B.,
RA   Zhou S.;
RT   "The genome and transcriptomes of the anti-tumor agent Clostridium novyi-
RT   NT.";
RL   Nat. Biotechnol. 24:1573-1580(2006).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; CP000382; ABK61971.1; -; Genomic_DNA.
DR   RefSeq; WP_011721851.1; NC_008593.1.
DR   AlphaFoldDB; A0PZP4; -.
DR   SMR; A0PZP4; -.
DR   STRING; 386415.NT01CX_1773; -.
DR   PRIDE; A0PZP4; -.
DR   EnsemblBacteria; ABK61971; ABK61971; NT01CX_1773.
DR   KEGG; cno:NT01CX_1773; -.
DR   PATRIC; fig|386415.7.peg.876; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000008220; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   CDD; cd03280; ABC_MutS2; 1.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..785
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000093352"
FT   DOMAIN          710..785
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         332..339
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   785 AA;  88380 MW;  CFAA6C6C03AB3CE3 CRC64;
     MNEKSLRVLE FNKIKDELKK YTQTSAAKDL IERLHPYESA YEVREHLMET EEAFKISIKK
     GDAPFSGLYD IREAISKAQR RFTLFPSELL RVANLLRASR RFKGYVKSDD LSEKYEVLES
     ITEGLVPLNG LEEEISKCII GEEEISDRAS TTLFNIRRSL KDKTSSIKAR VNSLIRTYSS
     HLQENIYTVR GERYVLPVKV EHKGAVPGLV HDQSASGATL FIEPMSLVDL NNEIKELRLK
     EKAEIDRILA FLSGKVYENV DVIKVDADIL WELDFIFAKA KYAQKLGAIM PIISEDGHFN
     IINAKHPLID PKKVVENNIY LRDGITSVVI TGPNTGGKTV TLKTVGLLHI MAMSGLMITA
     SQGSTISFFK EVFADIGDEQ SIEQSLSTFS SHMTNIVNII DSADENSLVL FDELGAGTDP
     TEGAALAVSI LENLRKRKTK VIATTHYSEL KAYALKVDNV ENASVEFDVE TLRPTYRLLI
     GVPGKSNAFE ISKRLGLPDY IIEDAREGIS EETLKFEDLI QSLQHKNIKA QEHARKAESA
     KEEAVKLKEK YESKLDKFQD IREKAILNAQ KEAKEIIKEA KEEADKILKD IRELERMGYS
     SDVRKLLEEN RKKLKDKLEK TESKLNQPKE VGEAVTNVSE GDELYLPKFE TKVMVLTNPD
     NKGDVQVQAG IMKIKVNIKD LRKTKETKIE KRQRKKKQMS LNLKSVATSV DLRGMDSEEA
     TYTADKYLDD ACMSGLSEVT IIHGKGTGVL RTAINDMLKR HPHVKSYRLG NYGEGGNGVT
     VVELK