ID   MUTS2_GEMAT             Reviewed;         819 AA.
AC   C1A4A9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=GAU_1892;
OS   Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC
OS   100505).
OC   Bacteria; Gemmatimonadetes; Gemmatimonadales; Gemmatimonadaceae;
OC   Gemmatimonas.
OX   NCBI_TaxID=379066;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T-27 / DSM 14586 / JCM 11422 / NBRC 100505;
RA   Takasaki K., Ichikawa N., Miura H., Matsushita S., Watanabe Y., Oguchi A.,
RA   Ankai A., Yashiro I., Takahashi M., Terui Y., Fukui S., Yokoyama H.,
RA   Tanikawa S., Hanada S., Kamagata Y., Fujita N.;
RT   "Complete genome sequence of Gemmatimonas aurantiaca T-27 that represents a
RT   novel phylum Gemmatimonadetes.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; AP009153; BAH38934.1; -; Genomic_DNA.
DR   RefSeq; WP_012683381.1; NC_012489.1.
DR   AlphaFoldDB; C1A4A9; -.
DR   SMR; C1A4A9; -.
DR   STRING; 379066.GAU_1892; -.
DR   EnsemblBacteria; BAH38934; BAH38934; GAU_1892.
DR   KEGG; gau:GAU_1892; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_0; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000002209; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..819
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000202681"
FT   DOMAIN          744..819
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         339..346
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   819 AA;  88966 MW;  551130F0FF23C5AD CRC64;
     MNAHALGILE FSRLLAHVAG RATSAPGAAA VRALTPRTDR EWIEAEHARV RAVRALVASE
     LGWPTEPIPD IGEPLRRLRI EGLSWTALEL LQGATLLRSS RRTRATLRDP RRPAIMLAYL
     VRYAEALVDL EPREQAIERA IGDDGTVRDD ASPTLRKVRR DLRETEGQLV RLLEREMGKL
     EAHHQVSDLS VTMRNGRWVM PMRREARGYV GGIVHDSSGT GATIYVEPPA AVEFGNRVRE
     LEIEEQREVE RVLRALTDEI RPYHDAIGGA YDALVALDSL YARARYAIEA QCAPVTFGEP
     SAGFRIVDGR HPLLLASGGA VVPFDLTLHA GERTMLVSGP NTGGKTVLLK AIGLISMMAQ
     CGVPAPLGET SQLAVFDDLY ADVGDEQSIE ASLSTFSAHL KNLGEILRSA TTSSLVLIDE
     LGSGTDPAEG AALGGAILET LTRRGTLTLA TTHLGQLKLL ATDVEGVVNA SLQFDAVQLA
     PTYRLLKGVP GRSYGLSIAR RLQIDEAVIQ RAEERLPSGE RDMAVLLADV EAREALLADR
     ERLMEIDQEK LRARLATVGD RELKVRERER EAERSARQEA RRFLLEARGQ VERAIADVKR
     QAQVEGEAFE ETARAARRSI EEAAAEQGEA VAYVGLRGER DRARVDAKRG AAAAAANPSL
     GRTLRPERGA VAPLGEGDHV IVSTLDGKQG RIVSVRGQDA RVAVGSLTVT VPLRTLTRSA
     AAPVSMYRTP ILGDVPEVEP VREVDVRGLR VDEVDDQVLQ ALDAAVRNDL RELRIIHGKG
     TGALRSRVSE MLKKDTRVTG FRLGAWNEGG AGVTVAELA