ID   MUTS2_HALMA             Reviewed;         947 AA.
AC   Q5UYI1;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS 2 {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=rrnAC2937;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV47672.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY596297; AAV47672.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_049939073.1; NZ_CP039138.1.
DR   AlphaFoldDB; Q5UYI1; -.
DR   SMR; Q5UYI1; -.
DR   STRING; 272569.rrnAC2937; -.
DR   PRIDE; Q5UYI1; -.
DR   EnsemblBacteria; AAV47672; AAV47672; rrnAC2937.
DR   GeneID; 40153767; -.
DR   KEGG; hma:rrnAC2937; -.
DR   PATRIC; fig|272569.17.peg.3496; -.
DR   eggNOG; arCOG02897; Archaea.
DR   HOGENOM; CLU_002472_10_0_2; -.
DR   Proteomes; UP000001169; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..947
FT                   /note="DNA mismatch repair protein MutS 2"
FT                   /id="PRO_0000224423"
FT   REGION          623..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..916
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        841..866
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        867..884
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         659..666
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   947 AA;  102194 MW;  E4BC7AB4A69E4ACC CRC64;
     MDAALGPPEQ MAELEEDLTP MMAQYYELCR QYDDALVLFQ VGDFYEAFCA AAKRVARLCE
     ITLTQREDST GEYPMAGIPI DNAESYVETL LDAGYRVAIA DQVEDPDEVS GVVERAVTRI
     VTPGTLTESE LLGGADNNYV AALTAGERYG LALLDISTGD CYATSVGSES AVADELSRFG
     PAEAIVGPDV DVDRDAVFGP ACLVTRYDAD AFAQDRAEDR VGQYFGPPER LLAGGAEIRA
     CGGLLAYAEY TRGSSGAVGP DGEPVDPDVD PAGTLDYLNH LTRYDPREYM LLDAVAVESL
     ELFKRRSVRG HENRTLVDTV DETACALGRR KLTDWLRRPL LDADRIEARH GAVAELQRDP
     ATREELSALL AEVYDLERLI SRVSRGRANA RDLRSLAATL SVVPDIRDHL ADADARLLAD
     LHATLDPLAE TREEIEAAIR PDPPQQVTEG GVIREGYDEE LDRLRSTEQS GKEWIDELEA
     SERERTGIDS LKVGHTSVHG YYIEVTNANL DAVPEDYQRR QTLKNSERYY TPALKEREDE
     ILRAESAADD LEYDLFCAVR DEVADEAERV QALADRLARL DVLVSFAEVA AQYDYCRPTV
     GSDGIDVTAG RHPVVERTED AFIPNDTHLG SGPVPASRDG SDDGVTADDI QPFLAVVTGP
     NMSGKSTYMR QVALICLLAQ SGSFVPAKAA DLPILDRVFT RVGASDDIAG GRSTFMIEMT
     ELATILDAAT ENSLVLLDEV GRGTSTADGL AIARAVTEYL HDEVGAYTLF ATHHHDLTAV
     AAALSGATNR HFETSREDGD VRFDHELAPG PAAASYGVEV ASMAGVPDSV VERSRDLLAD
     AETADTGVEA TRETEVASEP RPGTRADSET DSTATETTGP TENGAASAPA GEATSDDHAQ
     EVFQTNGAAA EDELPESVAQ QLASLDVATM TPIEAMNALA DLQDRIE