ID   MUTS2_HALSA             Reviewed;         863 AA.
AC   Q9HSL6;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutS 2;
GN   Name=mutS2; OrderedLocusNames=VNG_0172G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE004437; AAG18788.1; -; Genomic_DNA.
DR   PIR; H84177; H84177.
DR   RefSeq; WP_010902083.1; NC_002607.1.
DR   AlphaFoldDB; Q9HSL6; -.
DR   SMR; Q9HSL6; -.
DR   STRING; 64091.VNG_0172G; -.
DR   PaxDb; Q9HSL6; -.
DR   EnsemblBacteria; AAG18788; AAG18788; VNG_0172G.
DR   GeneID; 5952408; -.
DR   KEGG; hal:VNG_0172G; -.
DR   PATRIC; fig|64091.14.peg.124; -.
DR   HOGENOM; CLU_002472_3_1_2; -.
DR   InParanoid; Q9HSL6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 1024at2157; -.
DR   PhylomeDB; Q9HSL6; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS 2"
FT                   /id="PRO_0000115176"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   863 AA;  92663 MW;  6C280F55F5DD513C CRC64;
     MDAALGPPDA MAASEGDLTP MMSQYFELTR RYDDALVLFQ VGDFYELFCA AAETAARICE
     VTLTAREDST GQYPMAGVPI DTAEPYIEAL LDAGYRVAVA DQVQDPDEVS GVVDRAVTRV
     VTPGTVTEDE LLGGADNNFV AALAGGRDAD AGFGLALLDV STGDCYATRL GDEARVRDEL
     GRFTPAELVV GPGVDADRFA DEAFVAAYDD DAFEPAAARE RVADYFGGED VLPTTAELRA
     CGALLSYAEY TRGGAGDSQR LTYLNHVTRY SPTEHLQMDA VALRSLELFE QRSVHGTDGT
     ALVDVLDETA CALGRRKLTD WLRRPLVDSD AIAARHDAVG ELVADPLSRE ELHEHLRDVY
     DIERLVSRVS RGRANARDLR ALADTLAVVP EVRGLLADAD ARKLQSLREA LDDLPEIRGL
     LDRAIVADPP QELTDGGVIR DGYDERLDDL RATERAGKQW VDDLEASERE RTGVDSLKVG
     QNSVHGYYIE VTKANMDAVP EDYQRRQTLK NAERYVTPEL KEREEEIVRA EQRAQDLEYE
     LFVGIRERVA EAAERMQAVA RALAAVDALA SFAAVAAAHD YTKPVMGGDG IHIEGGRHPV
     VERTESGFVP NDTTLNDDRR VAVITGPNMS GKSTYMRQVA VIVVLAQAGC FVPAAAAELR
     VVDRVFTRVG ASDDIAGGRS TFMVEMTELA SILRAATDES LVLLDEVGRG TATTDGLAIA
     RAVTEHIHDA VGATTLFATH HHELTADADR LPDALNLHFA ATRGDDGVAF EHAVRAGAAT
     ASYGVEVART AGVPEPVVDR ARELLDAPAT ADGGDGGTTP TADANGQRGA AAGIVAELRD
     VSVAELTPIE ALNVLNDLAS RVD