ID   MUTS2_LACP3             Reviewed;         786 AA.
AC   Q03AZ5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=LSEI_0791;
OS   Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS   CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=321967;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 / NRRL
RC   B-441;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; CP000423; ABJ69627.1; -; Genomic_DNA.
DR   RefSeq; WP_011674280.1; NC_008526.1.
DR   RefSeq; YP_806069.1; NC_008526.1.
DR   AlphaFoldDB; Q03AZ5; -.
DR   SMR; Q03AZ5; -.
DR   STRING; 321967.LSEI_0791; -.
DR   EnsemblBacteria; ABJ69627; ABJ69627; LSEI_0791.
DR   KEGG; lca:LSEI_0791; -.
DR   PATRIC; fig|321967.11.peg.793; -.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   Proteomes; UP000001651; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding.
FT   CHAIN           1..786
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000093362"
FT   DOMAIN          711..786
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         333..340
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   786 AA;  86010 MW;  E46ACBD144397EA3 CRC64;
     MNEKILKTLE YDKIQQALLG QVVTANGRQL VQAMQPLTDP VAVQQALDET ADGASALRLK
     GGIPVPQLEN IDPALKRVDI GAVLNGQELA SISRVLQTVS AIDKFLTDLQ DQIDFRQLYT
     LQESLTVLPQ LSRRLKTAVD PDGTLTDEAS PQLHGVREQI KSIEGEIRGK MTNYTRGAQS
     KYLSDPIVTI RDDRYVIPVK AEYRAKFGGV VHDQSATGQT LFIEPQAIVA LNNRLREAQL
     AEVAEINRIL AELSNELAPY TGQIKANAAV LGHFDFINAK ARLAKAEKAT EPLVSADNDV
     LLRDARHPLI DPHKVVGNDI PLGDKYQAMV ITGPNTGGKT ITLKTLGLLQ LMGQSGLFIP
     ADDESRIGIF DEVFADIGDE QSIEQNLSTF SAHMDNIVHI LKQLSQNSLV LFDELGAGTD
     PQEGAALAIA ILDAVGEVGA YVVATTHYPE LKLYGYNTAK TINASMEFDS KTLQPTYRLL
     VGVPGRSNAF DISARLGLPG VIVERAKSMI SSDSHELNNM ISDLEKQRKA AETAYEAARR
     QLADAQSVHD ELAAAYKKFT TERDAQLQQA KDKANTLVDK AQTKADKIIK QLRQMQLTNP
     GTVKENQLIA AKTALKQLHQ DEPLQKNRIL RREREKQALH VGDEVKVASY DQTGTLLEQF
     DKKHWQVQLG ILKMKVPTDE LKKIKSSKQS AAQRPVVKVS GGGMSGPSTT LDLRGERYDQ
     AMADLDQYID AALLAGYPSV TIIHGLGTGA IRNGVTQYLK RNRQVKTYGF APQNAGGSGA
     TIVNFK