ID   MUTS2_MARSD             Reviewed;         769 AA.
AC   C6BSW8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=Desal_1610;
OS   Maridesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIMB 8403 /
OS   VKM B-1763) (Desulfovibrio salexigens).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Maridesulfovibrio.
OX   NCBI_TaxID=526222;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14822 / DSM 2638 / NCIMB 8403 / VKM B-1763;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA   Wall J.D., Arkin A.P., Dehal P., Chivian D., Giles B., Hazen T.C.;
RT   "Complete sequence of Desulfovibrio salexigens DSM 2638.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; CP001649; ACS79672.1; -; Genomic_DNA.
DR   RefSeq; WP_015851488.1; NC_012881.1.
DR   AlphaFoldDB; C6BSW8; -.
DR   SMR; C6BSW8; -.
DR   STRING; 526222.Desal_1610; -.
DR   EnsemblBacteria; ACS79672; ACS79672; Desal_1610.
DR   KEGG; dsa:Desal_1610; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_7; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000002601; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..769
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000202677"
FT   DOMAIN          694..769
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         335..342
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   769 AA;  84975 MW;  988239D6CAF18B52 CRC64;
     MEPRSLQLLE FPKVLNVLSG HCVSTSGAEA CLALSPMDDA GSINSTAQFF RQGQNFVKET
     GFRLGTFPPL EGLFQYLVKP NNVLDADALY ALVQTLGQAR TLKEALEIAE KREWDTILEF
     LEGVSWPEKT FSGLKRCLDQ DGNIKDESSP ELYDIRQSIR SLHQRCSKKV RDFIHGEDIS
     RFLQDDFMTI TNDRYVLPLK TNFKGRLQGI VHDYSNTGET CYFEPMFLVE LNNSMQELKQ
     QERTEELKIL TYLTGLVRSE YDQCEAAYGF LVEYDVLQAK INFADAVKAV AVDVQSGAGF
     DLRGARHPLL ASAVGGVNPL NIELPTDQKV LIVSGGNAGG KTVCLKTVGL LSAMAFSGIP
     VPVEKGSVLP LFKEIFVIMG DEQSLEENVS TFSAQIQSIS RIWDSMDSST LFILDEFGSG
     TDPAQGAALA QAVVDGLLEN GVTCFAATHF PALKTYALVT EGVRAASVLF DPSTKKPLFS
     LAYDQVGASI ALDVAREHGF PESLLAKAEQ YLLMEGSDSG SVMNRLNELA VSREKELEEM
     DRIKAKLESK RAKLEEKFER ERLTVLADVK KQAQSVLKEW QDGKIGRKQA LKKLSEARST
     IGGDEKPKSD VKPFSFDDIK VGKPILNISW NRKGVVIEKD ERKKRVKVDM DGVAMWIPAD
     QLGPVGKKAV QEKVRQVTEK ADKKAPKGEM TLKIDLRGKR ADVAISELDR FFDQALLRGA
     TELEIVHGRG TGALRREVHI FLDDNPAVAG YSLAPEDRGG DGMTEVELV