MUTS2_PEDPA
ID MUTS2_PEDPA Reviewed; 785 AA.
AC Q03ES2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=PEPE_1259;
OS Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 /
OS 183-1w).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Pediococcus.
OX NCBI_TaxID=278197;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR EMBL; CP000422; ABJ68300.1; -; Genomic_DNA.
DR RefSeq; WP_011673576.1; NC_008525.1.
DR AlphaFoldDB; Q03ES2; -.
DR SMR; Q03ES2; -.
DR STRING; 278197.PEPE_1259; -.
DR PRIDE; Q03ES2; -.
DR EnsemblBacteria; ABJ68300; ABJ68300; PEPE_1259.
DR GeneID; 33061803; -.
DR KEGG; ppe:PEPE_1259; -.
DR eggNOG; COG1193; Bacteria.
DR HOGENOM; CLU_011252_2_1_9; -.
DR OMA; IHAIIND; -.
DR OrthoDB; 256392at2; -.
DR Proteomes; UP000000773; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..785
FT /note="Endonuclease MutS2"
FT /id="PRO_1000093375"
FT DOMAIN 710..785
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT BINDING 334..341
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 785 AA; 88235 MW; B916F3D628ED76B4 CRC64;
MNKKILDVLE YDKIKQSIRQ FIATENGTKE LRELVPSSDE TEVRNALKQT LDAVNIYRLK
NGIPVPRLED VTEALQRLKI DAALNGQELA QIGRILRATR TVINFFDDLE NEEIEIIALD
QVIEQLVTIP EVEERLSNSI EGNGHLLNSA SSELRRIRAS ITRIESDVRS RMEKFTRGNN
VKYLSEPIVT IRNERYVIPA RVEYRSKFGG VVHDQSSSGQ TLYVEPESVV DLNNELRQNQ
VAEVHEEQRI LQELSALVAP YTDTLKDNSR ILGHLDLLNA KAQYAHQLKA TEPQISASNE
INLREARHPL IDQKKVVSND IRLGGEYETL VITGPNTGGK TITLKTVGLL QLMAQSGMFI
PANENSTVRI FEEIFADIGD EQSIEQNLST FSSHMDNTIR ILGNLNERSL ALFDELGAGT
DPKEGAALAI AILDKVRSTG AVSMTTTHYP ELKTYGYERM GTINASMEFD VDTLQPTYKL
LLGIPGQSNA FEISKRLGLD SDIISQARGL VDQDSQDLNN MIKDLTTRQK RAQKINQQAV
ELLKQAEEYH QTLVKGVDSL NSQRSNLIES AKEDANRIVN DSQAEADRII KRLRKLEHST
GSFKENDLID AKSKINALHQ DTNLKRNKVL RRAKEAQKFH ENDEVVVLTY GQRGELLRQV
DKKHWEVQMG IMKMKVAVDE LEKVKPDKTV KRRVHNSVQR TASAGVKTTL DLRGKRYEEA
LTETDRYIDA ALLAGYDEVT IVHGKGTGAL RSGITKYLKN NRRIKAFEYA PANAGGNGAT
IVHFK