ID   MUTS2_STAES             Reviewed;         782 AA.
AC   Q8CPL6;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=SE_0837;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE015929; AAO04434.1; -; Genomic_DNA.
DR   RefSeq; NP_764392.1; NC_004461.1.
DR   RefSeq; WP_001833037.1; NZ_WBME01000035.1.
DR   AlphaFoldDB; Q8CPL6; -.
DR   SMR; Q8CPL6; -.
DR   STRING; 176280.SE_0837; -.
DR   EnsemblBacteria; AAO04434; AAO04434; SE_0837.
DR   GeneID; 50019025; -.
DR   KEGG; sep:SE_0837; -.
DR   PATRIC; fig|176280.10.peg.810; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   CDD; cd03280; ABC_MutS2; 1.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding.
FT   CHAIN           1..782
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_0000115234"
FT   DOMAIN          707..782
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         336..343
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   782 AA;  88719 MW;  A6DA31D686500431 CRC64;
     MRQKTLDVLE FEKIKSFVAD ETISDLGREK VQEMAPASNF DTVEFQMNET DEISQIYNKH
     RLPSLSGLAK VSPLVHRASI GGVLNVGELN RIKRLVQVQN QFKTFYNQML EEDEEVKYPI
     LHDKMNHLPI LTDLFKEINE KCDAHDLFDH ASYTLQSIRS KISRTNQRIR QNLDRIVKNQ
     GNQKKLSDAI VTVRNDRNVI PVKAEYRQDF NGIVHDQSAS GQTLYIEPNS VVEMNNQISR
     LRNDEAVERE RILTELTGLV SAESDALLVA ESVMGQIDFL IAKARYARTI KGTKPTFKEE
     RTIYLPNAFH PLLDKDTVVA NTIEFIDDVE TVIITGPNTG GKTVTLKTLG LIIVMAQSGL
     LIPTLDGSQL SIFENVYCDI GDEQSIEQSL STFSSHMKNI VEILQDADQN SLILFDELGA
     GTDPSEGAAL AMSILDYVRR LGSLVMATTH YPELKAYSYN REGVMNASVE FDVDTLSPTY
     KLLMGVPGRS NAFDISKKLG LSLNIINKAK TMIGTDEQEI NAMIESLEHN SKRVDQQRIE
     LDRLVREAQE THDALSKQYQ QYQNYEKSLM EEAKEKANQR VKSATKEADE ILKELRNLRD
     HKGAEVKEHE LIDKKKQLDD QYEAKSIKQH VQKKKYDTIH AGDEVKVLSY GQKGEVLELV
     GNEEAVVQMG IIKMKLPIED LEKTKKKKEK PTKMVTRQNR QTIKTELDLR GYRYEEALNE
     LDQYLDQAVL SNYEQVYIIH GKGTGALQKG VQQHLKKHKS VRQFRGGMPN EGGFGVTVAE
     LK