ID   MUTS2_SYMTH             Reviewed;         793 AA.
AC   Q67QE3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=STH1115;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; AP006840; BAD40100.1; -; Genomic_DNA.
DR   RefSeq; WP_011195247.1; NC_006177.1.
DR   AlphaFoldDB; Q67QE3; -.
DR   SMR; Q67QE3; -.
DR   STRING; 292459.STH1115; -.
DR   PRIDE; Q67QE3; -.
DR   EnsemblBacteria; BAD40100; BAD40100; STH1115.
DR   KEGG; sth:STH1115; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_9; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   CDD; cd03280; ABC_MutS2; 1.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..793
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000093409"
FT   DOMAIN          717..792
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   REGION          611..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        615..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         329..336
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   793 AA;  87439 MW;  457DB102EAAAFCC3 CRC64;
     MDERTLRTLE FAKIKEMLAE RTATSLGREV VESLAPATDF LEVQHRQAET SEARRLYEGG
     HAIPLGGLHD LRAHVQRAVR GGVLDPGDLL DVADTAASSR RLKRFLEEQE GLPILTALSR
     MLGTFHHLEA EIRQAVDEHG EVRDDASPAL AEIRRSMRIL QNRMKERLDA FVRGSAAKYL
     QDPIVTIREG RFVVPVKIEY RAQVPGIVHD QSASGSTLFI EPMAIVEMNN DLRELALKEH
     EEVERILARL SSLVAGEADA LLDTLQAVAQ IDFASAKGKL SLDLDCTEPE LVREPILEIH
     KGRHPLLKGR VVPIDVHIGI TFDTLVITGP NTGGKTVALK TMGLFVLMAQ AGLHLPAGHG
     TRVGVFQQVF VDIGDEQSIE QSLSTFSGHM TNIIRILDAL EGPALVLLDE LGAGTDPTEG
     AALAMSILEH LHKRGAKTVA TTHYSELKTY AYTRSRVENA SVEFDVETLR PTFRLLIGVP
     GSSNAFEISR RLGLSPHIVD RARQFLTQEQ ERVEDLIQGI HATRAELEKE RAEAHRLRAE
     AQRMREEYER RYGDAQRKAA ETVEKARAQA QQILATARRE AEAVIAELKQ ALREQREAER
     MQAIQSARSR LARARQAVEP TEEEQRARRR GEVPRGLKPG DKVRVVSLDT TGYVLSEPDA
     DGNVLVQAGI LKMTVSLTDL ERASEEQPAA GAGGPARMRT HGKGLAVSKA REMSPEVDLR
     GLMVEEALER VDKFLDDAVL AGLPQVRIIH GKGTGALRKA VTEALRHDRR VESYRLGGVG
     EGGDGVTVAK LRE