MUTS2_THESQ
ID MUTS2_THESQ Reviewed; 757 AA.
AC B1LC69;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=TRQ2_1541;
OS Thermotoga sp. (strain RQ2).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga;
OC unclassified Thermotoga.
OX NCBI_TaxID=126740;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RQ2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA Richardson P.;
RT "Complete sequence of Thermotoga sp. RQ2.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR EMBL; CP000969; ACB09877.1; -; Genomic_DNA.
DR RefSeq; WP_012311177.1; NC_010483.1.
DR AlphaFoldDB; B1LC69; -.
DR SMR; B1LC69; -.
DR PRIDE; B1LC69; -.
DR EnsemblBacteria; ACB09877; ACB09877; TRQ2_1541.
DR KEGG; trq:TRQ2_1541; -.
DR HOGENOM; CLU_011252_2_1_0; -.
DR OMA; IHAIIND; -.
DR OrthoDB; 256392at2; -.
DR Proteomes; UP000001687; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF160443; SSF160443; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01069; mutS2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW Nucleotide-binding.
FT CHAIN 1..757
FT /note="Endonuclease MutS2"
FT /id="PRO_1000093410"
FT DOMAIN 681..756
FT /note="Smr"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT BINDING 321..328
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ SEQUENCE 757 AA; 86434 MW; 0CFB802FB5A6A05C CRC64;
MDYLESLDFP KVVEIVKKYA LSDLGRKHLD TLKPTVNPWD ELELVEELLN YFARWGEPPI
KGLNDISQEV ERVKSGSALE PWELLRVSVF LEGCDILKKD FEKREYSRLK ETFSRLSSFR
DFVEEVNRCI EQDGEISDRA SPRLREIRTE KKRLASEIKR KADDFVRTHS QILQEQMYVY
RDGRYLFPVK ASMRNAVRGI VHHLSSSGAT VFLEPDEFVE LNNRVRLLEE EERLEISRIL
RQLTNILLSR LNDLERNVEL IARFDSLYAR VKFAREFNGT VVKPSSRIRL VNARHPLIPK
ERVVPINLEL PPNKRGFIIT GPNMGGKTVT VKTVGLFTAL MMSGFPLPCD EGTELKVFPK
IMADIGEEQS IEQSLSTFSS HMKKIVEIVK NADSDSLVIL DELGSGTDPV EGAALAVAII
EDLLEKGATI FVTTHLTPVK VFAMNHPLLL NASMEFDPET LSPTYRVLVG VPGGSHAFQI
AEKLGLDKRI IENARSRLSR EEMELEGLIR SLHEKISLLE EEKRKLQKER EEYMKLREKY
EEDYKKLRRM KIEEFDKELR ELNDYIRKVK KELDQAIHVA KTGSVDEMRE AVKTIEKEKK
DLEQKRIEEA TEEEIKPGDH VKMEGGTSVG KVVEVKSGTA LVDFGFLRLK VPVSKLKKAK
KEEKEESSAV SYRPSSFRTE IDIRGMTVEE AEPVVKKFID DLMMNGISKG YIIHGKGTGK
LASGVWEILR KDKRVVSFRF GTPSEGGTGV TVVEVKV