ID   MUTS2_TREDE             Reviewed;         818 AA.
AC   Q73MQ8;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Endonuclease MutS2 {ECO:0000255|HAMAP-Rule:MF_00092};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00092};
GN   Name=mutS2 {ECO:0000255|HAMAP-Rule:MF_00092}; OrderedLocusNames=TDE_1450;
OS   Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153
OS   / KCTC 15104).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243275;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104;
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S.A., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H., Selengut J.,
RA   Ren Q., Brinkac L.M., Madupu R., Kolonay J.F., Durkin S.A., Daugherty S.C.,
RA   Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K., Tsegaye G.,
RA   Malek J.A., Ayodeji B., Shatsman S., McLeod M.P., Smajs D., Howell J.K.,
RA   Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q., Sodergren E.,
RA   Baca E., Weinstock G.M., Norris S.J., Fraser C.M., Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola with
RT   other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity. {ECO:0000255|HAMAP-
CC       Rule:MF_00092}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00092}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00092}.
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DR   EMBL; AE017226; AAS11967.1; -; Genomic_DNA.
DR   RefSeq; NP_972056.1; NC_002967.9.
DR   RefSeq; WP_002679109.1; NC_002967.9.
DR   AlphaFoldDB; Q73MQ8; -.
DR   SMR; Q73MQ8; -.
DR   STRING; 243275.TDE_1450; -.
DR   EnsemblBacteria; AAS11967; AAS11967; TDE_1450.
DR   GeneID; 2741413; -.
DR   KEGG; tde:TDE_1450; -.
DR   PATRIC; fig|243275.7.peg.1391; -.
DR   eggNOG; COG1193; Bacteria.
DR   HOGENOM; CLU_011252_2_1_12; -.
DR   OMA; IHAIIND; -.
DR   OrthoDB; 256392at2; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.30.1370.110; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Endonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..818
FT                   /note="Endonuclease MutS2"
FT                   /id="PRO_1000093411"
FT   DOMAIN          743..818
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
FT   BINDING         352..359
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00092"
SQ   SEQUENCE   818 AA;  92265 MW;  7AED37B69936A209 CRC64;
     MTEHTLEVLQ FSRIREIIAS YCVTDEGKEF CLKKNPDTDI KKIEEEKKLG IDFLSLLRAY
     KAPPIKYRPP VLPFLEGIEV EGAALDIEGV YSVGLLALSV FSLHEWLSPF LENEDLNENS
     IVSFVKKIPD MLHLKNLVFS FIDENGELQD LPSLRAIKNK IRSIEDDIDK TMRNYFTNDA
     TRQMLQSNLP TVKDGRQVIA VRSNFKGRIP GIIHEYSQSG QTFYLEPEEI VLKNNDLIAA
     HAEYERELLR LLQDLTSQIA EHTENIKEAC EAITKLDCVA AASRWAHSNN CVFAGSIDLG
     LSHSIDKDGS HDSKGTPLAF YLHQARHPLL GKSAVPIDLK LSKDDRVLII TGPNTGGKTV
     SLKTAALFAL INQTGWPVPA GPLTRLPYFD FIACDIGDEQ SMDQSLSTFS AHMKNVSEII
     RRAGDKSLII LDELGSGTDP QEGCAIAMAV LDDLLEKKAF VFVTTHHGAL KNYGYSKESC
     VNASVEFNQN TLSPTYRILM GVPGESHAVD IAKRNGLPEH IIEKAHTYLG NNRADVSDLI
     KGLIQKHEDL NEFELQKKEE ELKLKEDRRR SDLKELQLKQ KELELKKDGI KRLDLFFEEK
     RKFLENLVRE LREGELSREK TLSVKKWIDD FEKDLDKEHE ALKLEQTKID ERLHSSKEKN
     KAPQNPELRE GTRVIIKSLN RNGELIREEK KGKWLVAVDN LKLTIAEDDI EVCENQEKLK
     LSKPIVSIIS DTSAPSSRPS FELRLLGMRA EEAQKALQDQ MDLALVHGIT EFAIIHGKGH
     GILQELSHDF LKRSPYVKAF RFAKPEEGGS GKTIVSLG