ID   MUTSL_MIMIV             Reviewed;        1124 AA.
AC   Q5UQU6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Putative DNA mismatch repair protein mutS homolog L359;
GN   OrderedLocusNames=MIMI_L359;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
CC   -!- FUNCTION: May be involved in DNA-mismatch repair.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AY653733; AAV50628.1; -; Genomic_DNA.
DR   RefSeq; YP_003986863.1; NC_014649.1.
DR   SMR; Q5UQU6; -.
DR   GeneID; 9924979; -.
DR   KEGG; vg:9924979; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd00085; HNHc; 1.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR003615; HNH_nuc.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..1124
FT                   /note="Putative DNA mismatch repair protein mutS homolog
FT                   L359"
FT                   /id="PRO_0000247297"
FT   BINDING         779..786
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1124 AA;  130330 MW;  CB6684F2975FB15C CRC64;
     MVSHLIFTDF YSKKFQKMKY SSDSEDNKKE TIYTYYFTEQ EKYAKIYGSK TLVFIQIGKF
     YEAYCTRKKG YVNLAELEPL LNIKFIRRDD KPIKDGKPPK PNQFGINCVA ISKNLSIMVN
     HGYTVVLFDQ KSDGETIERE CVGVYSPGTY LSDIQMQEAN YLLSVYISEE KQLTCNKNLM
     AIGLSLVDIS TGTNIIHEFY SNKFDERFGL DELVRMMQTF RPVESVIYYH PVNIDESAIK
     NVKLYLELDK YHNVHFYIYH NNKGEDALNL LTENSFKINF QNDYLAQIYE MNNQLTLNKK
     QSPLEILGLE RRNYAAVSLM MMLKYIAEHN VLLLKNLSYP EIYLYNKHLI LGNNAIEQLN
     VIDSNNLELY NSKISSVFDV INKTSTPMGK RFLKDNLLNP LSQENKKEII KRYDYIEALI
     QGNIFKEIKT ELKNIYDIER LHRRMAVGAI VPYEFTRLDN YYKATNRVYS VIKDNDVIKS
     IIPMNIFKEF VEYQVKYNKE FDTEKMANHA NFGEISESFF RKGIHEDLDK IQEKIDYIQS
     LIKSTNYYFT SIIKDKCKKL GNKEILSMES NDREGYYFTI SKSNEKILKQ EIDKKKGIIK
     IDLTIGETLD IKKDDIVFKQ LPKGRTKVFM AQLAEYTIKL PSLTEKLTEL IKKKFIKSMV
     TYYSNHKSML HQITRFVSEI DFLVSGAIVA KEYYYCKPSI LSENSIPSYL QAKDLRHVIV
     ERLCDETVYV PNDIELGNVP NIIHTKNKKD SSIEEVSIDE TDKFKKVLGK KCNGIVLFSN
     NWAGKSTCMK SVGIAIILAQ IGYYVPATEF NYEPYMALYA RITGNDNIFK GLSSFALEMT
     ELDAILMRTE KQGSNTLVIG DEVCKGTEDI SGRAIVASAL VSLSECDSTF IFSSHLHDIQ
     NIDEVKSLNN LRVYHLRTEY DEENDCIIFD RKLMPGSGPS VYGLLVARYL VKNPKFINRA
     EIIKKRLTND INVNLIPKKS NYNKDLLVKQ CMICRYIPTT EYHKELESHH IHFQKNCWTD
     GKIKEKPYLS KNKLYNLVVL CRKCHNKVHQ GEIIINGYTD TTIGPLLDYN MDIKKKIING
     IKAVDDLEKS FKFSNNKSQI QKTKNTTVKK IQTSKKNNLV CEYA