ID   MUTS_ACAM1              Reviewed;         883 AA.
AC   B0CF30;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AM1_5596;
OS   Acaryochloris marina (strain MBIC 11017).
OC   Bacteria; Cyanobacteria; Synechococcales; Acaryochloridaceae;
OC   Acaryochloris.
OX   NCBI_TaxID=329726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBIC 11017;
RX   PubMed=18252824; DOI=10.1073/pnas.0709772105;
RA   Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J.,
RA   Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D.,
RA   Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y.,
RA   Taylor H.L., Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M.,
RA   Blankenship R.E., Touchman J.W.;
RT   "Niche adaptation and genome expansion in the chlorophyll d-producing
RT   cyanobacterium Acaryochloris marina.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000828; ABW30546.1; -; Genomic_DNA.
DR   RefSeq; WP_012165766.1; NC_009925.1.
DR   AlphaFoldDB; B0CF30; -.
DR   SMR; B0CF30; -.
DR   STRING; 329726.AM1_5596; -.
DR   EnsemblBacteria; ABW30546; ABW30546; AM1_5596.
DR   KEGG; amr:AM1_5596; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_3; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000268; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..883
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335100"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          857..883
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         664..671
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   883 AA;  97886 MW;  D30E3C665DA94A1F CRC64;
     MSDSVAPDVP VIREGKNPAQ HRDRTTVDRE ALSPMMRHYV DLKDEYPQTI LLYRMGDFYE
     TFFEDACTIA QALELVLTSR QSGNEVGRVA MAGIPHHQLD RYSRLLVEKG FAVAICDQME
     DPAQAQGLVK REVTRVITPG TLLEEGMLNA RSNNFLAAFV LAGNHWGLAY ADISTGEFLT
     TQFSERETLA QELLRLQPSE VLFPTDAPDI QQILRPGEQS DLLPEGLPNQ FCYSLRSQTS
     FTQAEARQRI QEVYGVRSLE GLGCEHLPLA VRAAGGLLAY LEATQKDTHI PLQPLATYTL
     SQYLVLDHQS RRNLELTQTS RDGTFRGSLL WAIDRTRTAM GSRALRRWLL QPLLDLNDIQ
     ARQAAITELL PQTGFRKELQ NQLQKIYDLE RLAGRAGSGT ANARDLVALA ESLGQLTELS
     HKVAKCEAQY LQALQTVPPI LDQLAQRLRA HLVESPPISL TEGGLIKPSV NPELDQMRQQ
     IVSDQQWIAN LEKDERERTG ISTLKVGFNK AFGYFISISR AKADQAPDDY IRKQTLTNEE
     RFITPELKER EARIFTAQTE QFQLEYDLFV TLRTEVGEQA SLIRTVAAAV SAVDILVGLT
     EVAVYQGYCC PTMSDSREIQ ILDGRHPVVE QSLPPGFFVP NATELGSAPS AELTPHPDLV
     ILTGPNASGK SCYLRQVGLI QLMAQIGSYV PAQSARLGIC DRIFTRVGAV DDLATGQSTF
     MVEMNETANI LNHASSKSLV LLDEIGRGTA TFDGLAIAWS VAEHLAAVIQ ARTIFATHYH
     ELNELASLVE NVANYQVLVK ELPDQIIFLH QVCPGGASRS YGIEAGRLAG LPPSVIKRAK
     QVMKQIEQHS KIAVGLRKGN TQPRARKSSA ETEAKTQQFE LPF