ID   MUTS_ACET2              Reviewed;         870 AA.
AC   A3DDI3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Cthe_0777;
OS   Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC
OS   103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Acetivibrio.
OX   NCBI_TaxID=203119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL
RC   B-4536 / VPI 7372;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Wu J.H.D.,
RA   Newcomb M., Richardson P.;
RT   "Complete sequence of Clostridium thermocellum ATCC 27405.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000568; ABN52012.1; -; Genomic_DNA.
DR   RefSeq; WP_003516351.1; NC_009012.1.
DR   AlphaFoldDB; A3DDI3; -.
DR   SMR; A3DDI3; -.
DR   STRING; 203119.Cthe_0777; -.
DR   EnsemblBacteria; ABN52012; ABN52012; Cthe_0777.
DR   KEGG; cth:Cthe_0777; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002145; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..870
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071274"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   870 AA;  99390 MW;  2A9B8473D82795B6 CRC64;
     MASLTPMMQQ YLEIKEQYKD CILFFRLGDF YEMFFSDAEV ASRELEITLT GKDCGLEERA
     PMCGVPFHSA DSYIAKLISK GYKVAICEQI EDPALAKGLV KRDVIRIVTP GTVTDSAMLD
     EKKNNYLMSI YKNKNYYGIA CVDLTTGEFL STHITFGNTF NKLMDEIAKF SPSEIVVNGE
     FFHDENIKKT LKQRFDVYIS GLEDKFFEKE FSIQKVRNYF KDYVIEENAF DLYINASGAL
     LEYLEQTQKV NLSHIQNFNV YRIEEYMILD MATRRNLELT ETMREKNRKG SLLWVLDRTM
     TSMGGRTLRK WIEQPLINLH DIKDRLDAVN EFKERFMIRS EVRELLRAVY DIERLMTKVI
     LGSANCRDLI SIKHSIGQVP YIKELLRDLK ADLNVLSYNE LDTLTDVYEI IDKAIVDDPP
     VAVKEGGIIK EGFNEEVDRL RSASKDGKKW IAHLESKERE RTGIKNLKVG FNKVFGYYIE
     VTKSYYSQVP DDYIRKQTLA NCERYITPEL KEIENTVLGA EDRLVELEYQ IFVDVRNKVA
     KEINRLKTTA RSLARIDVLC SLAEVADRES YTMPEVTDDD KIEIKDGRHP VVEKIIGQEA
     FVPNDTYLDM DENQIAIITG PNMAGKSTYM RQVALIVLMA QIGSFVPAKS AKIGIVDRIF
     TRVGASDDLA AGQSTFMVEM SEVANILGNA TSKSLLVLDE IGRGTSTYDG LSIAWAVIEY
     IGEKIGARTL FATHYHELTE LEERIEGIKN YCISVEEKGE DIIFLRKILR GGADNSYGVQ
     VARLAGIPDP VIHRAKEILK KLEDADITRK EKRITRRKQP IEGQIDVFTF NAAQRSYDEV
     LNELKSLDIT TLTPLDAINV LYNLQKKVKG