ID   MUTS_ACHLI              Reviewed;         841 AA.
AC   A9NGL6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ACL_0883;
OS   Acholeplasma laidlawii (strain PG-8A).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae;
OC   Acholeplasma.
OX   NCBI_TaxID=441768;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG-8A;
RX   PubMed=21784942; DOI=10.1128/jb.05059-11;
RA   Lazarev V.N., Levitskii S.A., Basovskii Y.I., Chukin M.M., Akopian T.A.,
RA   Vereshchagin V.V., Kostrjukova E.S., Kovaleva G.Y., Kazanov M.D.,
RA   Malko D.B., Vitreschak A.G., Sernova N.V., Gelfand M.S., Demina I.A.,
RA   Serebryakova M.V., Galyamina M.A., Vtyurin N.N., Rogov S.I., Alexeev D.G.,
RA   Ladygina V.G., Govorun V.M.;
RT   "Complete genome and proteome of Acholeplasma laidlawii.";
RL   J. Bacteriol. 193:4943-4953(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000896; ABX81496.1; -; Genomic_DNA.
DR   RefSeq; WP_012242827.1; NC_010163.1.
DR   AlphaFoldDB; A9NGL6; -.
DR   SMR; A9NGL6; -.
DR   STRING; 441768.ACL_0883; -.
DR   PRIDE; A9NGL6; -.
DR   EnsemblBacteria; ABX81496; ABX81496; ACL_0883.
DR   GeneID; 66293869; -.
DR   KEGG; acl:ACL_0883; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_14; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008558; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..841
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075550"
FT   BINDING         596..603
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   841 AA;  96294 MW;  79AACDE7C78F06E6 CRC64;
     MSDISKYTPM MQQYLKIKED YADAIVFFRL GDFYEMFFDD AITASKVLEI TLTKKEAGQT
     VPMCGVPHHA AKVYIQKLIT KGFKIAIVEQ TSEPGKGLVE REVVQLITPG MIIDDDILPK
     NEYNFIGSVS LSEYGYILSY ADISTGDTFI LNGLTKQALT DEVSNLKLKE IVLTNTSDIY
     LLNFFKQESI LVSIYTNQEV QNTRIVRNLK EKHLKEAGSL LINYLEKESK LDLSHLMPFE
     SVIVDQYMRL DHQVLNHLEL TESLTGNINS TLIQWIDKTS TAMGSRLLRY ELTHPLKDKE
     LLEKRYDYIE AFTQFEPRNK LESILEQVYD LNRLVGRVSS NQTHARDLVQ LKTTLSLIPE
     FKEVLDSFDN PLIDEMNDKV DVFETLFQLL DASIENEPPL TVKEGGIIKD GYDETLDEFR
     SIAKNGDLWL EKFENEEKER TGIKNLKVGY NRVFGYFIEV SKGNIPLIQE EFGYIRKQTL
     ANAERYITED LKNAENKILS SKDRADKLEY EIFNQIKETA KTYTHELQLL SQIIASVDKY
     ISLSKVAEMY KYVRPKLNHN RIVDIENGRH PVVEQHVEFI KNHIHMKPSE IFILTGPNMS
     GKSTYMRMFA VITVMAQTGM FVPATSANLP IYDAIFTRIG SSDDISGGKS TFMVEMVEAN
     DALTYATENS LILFDEIGRG TATYDGLALA QAMIEYVHTQ IKAQMMFSTH YHELTKLSEK
     HDLITNLHVK AIEQKDHMVF LHQVELGSSD KSYGIQVAAL AHLPDPVIKR AKYLLKKLEK
     DGKGIDHNLF MFEEKVELGQ IIPHDIQDLL NHINDLDINQ MTPLDALIKL KYLQSLSKEK
     K