ID   MUTS_ACIAC              Reviewed;         890 AA.
AC   A1TNU7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Aave_2052;
OS   Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp. citrulli).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=397945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AAC00-1;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
RT   "Complete sequence of Acidovorax avenae subsp. citrulli AAC00-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000512; ABM32635.1; -; Genomic_DNA.
DR   AlphaFoldDB; A1TNU7; -.
DR   SMR; A1TNU7; -.
DR   STRING; 397945.Aave_2052; -.
DR   EnsemblBacteria; ABM32635; ABM32635; Aave_2052.
DR   KEGG; aav:Aave_2052; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002596; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335102"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         649..656
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  96806 MW;  1F33FB957A9C5FD1 CRC64;
     MDKGINLQND KEPSPMAEGN PADFSAHTPM MQQYLALKAG YPDTLVFYRM GDFYELFWAD
     AEKAARLLDI TLTQRGQSAG QPVVMAGVPF HALENYLGRL IRMGESVAIC EQVGEVGAAK
     GPVERKVVRV VTPGTLTDSE LLPDKAESML LAVHQAPRAR CGLAWLSVTQ GVVHLAECTH
     DEVGTWIARI GPSEVIYSAG VTERFEQQLQ ALRQGGVLSC PLSLRPDWQF DGALGARKLL
     EQLGAASLNA WDAQDLAHAH AASAALLSYA EHTQGRALTH IHAVRVQKND ELIALPPATR
     RNLELTRTLR GEDAPTLFSL LDTCMTGMGS RLLKTWLLEP RRDRTEARAR LAATAELRGD
     HGGTGSWQAL RAALRGVSDV ERITARIALR QVRPRELVAL CKTLHKAEQI AAEHRWQDPL
     LAGISGDLHA PPACGALLAG AILEEPSALV RDGGVIADGF DAELDELRGI QNHCDDFLLA
     LETREKARTL IPNLRVQFNK VHGFYIEVTS SYLDRIPDDY RRRQTLKNAE RFITPELKAF
     EDKALSAQER ALAREKWLYE QVLDQLQQHV PALTRAAQAI AALDALCALA ERSLTLGWCA
     PQFAAEPCIE IEGGRHPVVE ARLAETSAGA FIPNHTRLNA NTRMQIITGP NMGGKSTYMR
     QVALIVLLAS MGSHVPAAHC RLGPIDAIHT RIGAADDLAN AQSTFMMEMT EAAQILHAAT
     PHSLVLMDEI GRGTSTFDGL ALASGIATHL HDRTRAFTLF ATHYFELTEL AARHAHAVNV
     HVGATESGSD IVFLHEIQPG PASRSYGIHV ARLAGVPAPV LNHARHALSA LEERANEGET
     QVDLFAPPPE SEAPGISPVE AALQGIHPDS LSPREALDAL YQLKRLAQPG