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MUTS_ACIBC
ID   MUTS_ACIBC              Reviewed;         881 AA.
AC   B2HX50;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ACICU_01240;
OS   Acinetobacter baumannii (strain ACICU).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=405416;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACICU;
RX   PubMed=18411315; DOI=10.1128/aac.01643-07;
RA   Iacono M., Villa L., Fortini D., Bordoni R., Imperi F., Bonnal R.J.,
RA   Sicheritz-Ponten T., De Bellis G., Visca P., Cassone A., Carattoli A.;
RT   "Whole-genome pyrosequencing of an epidemic multidrug-resistant
RT   Acinetobacter baumannii strain belonging to the European clone II group.";
RL   Antimicrob. Agents Chemother. 52:2616-2625(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000863; ACC56552.1; -; Genomic_DNA.
DR   RefSeq; WP_001083258.1; NZ_CP031380.1.
DR   AlphaFoldDB; B2HX50; -.
DR   SMR; B2HX50; -.
DR   KEGG; abc:ACICU_01240; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000008839; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..881
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093601"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   881 AA;  97893 MW;  76D9D87566013815 CRC64;
     MNSAEIMADL SNHTPMMQQY LKVKKDYQHA LLFYRMGDFY ELFFEDAHLA AKLLGITLTH
     RGKANGNPIP MAGVPYHSAE GYLARLVKAG RTVAICEQVG EVTGKGPVER KVVRILTPGT
     LTDDALLTSY QSSNLVALCI HQNQIGFALL DLSAGIFKVQ QQDYKPEQLP IELARLMPSE
     ILIDEDLVDP NIIEQIKKHL DCPVTKRPNV DFNLNNAQKT LCDQFSVSTL SGFGLDPLPL
     AKAAAAALIH YAKETQKTAL PHIRSILLEQ SSDFIALDPI TRRNLEIIEP LFEHGTSLFQ
     LVNDCQTAMG GRLLSRTLMQ PVRDTALLDA RLDAIEQLIQ GYHESPVRLV LKEIGDIERV
     LSRVALGSAR PRDLVQLRHA CAQIPFLRNA LAPVVQAKKS KLLGQLDQEL GDFKSLHQHL
     MAAIVENPPV LLRDGNVIAE GYDAELDELR QIRDHAGQFL IDLEIKERER TGISTLKIGY
     NRVSGYYIEL TRAQAEQAPA DYIRRQTLKN AERYITPELK SFEDKVLSSE SRALAREKAL
     FEALLENLRE NIAHLQMMSS AIAQIDVIAN FAHQARLNNW ARPEFTPETG IKIQGGRHPV
     VEALSKAPFT PNDTFLDVQH RMAIITGPNM GGKSTFMRQT ALISLLAYCG SYVPARAAKL
     GPIDRIFTRI GSADDLSTGK STFMVEMTET SQILHHATNQ SLVLMDEVGR GTSTYDGLSL
     AWACVVDLTK RVKCLCLFAT HYFELTELGS EPGIDNYHVT AQELNGNLIL LHKVQQGPAS
     QSHGLQVAKL AGIPANVIKE AQKRLRILEK QQQQHLQTSV QSDLFATLDS EVTPSTQVIE
     KVIEVEVSSP ALDLLKQIEV DNLTPRQALE QLYELKAALN S
 
 
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