ID   MUTS_ACTP2              Reviewed;         864 AA.
AC   A3N2Q0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=APL_1602;
OS   Actinobacillus pleuropneumoniae serotype 5b (strain L20).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=416269;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L20;
RX   PubMed=18065534; DOI=10.1128/jb.01845-07;
RA   Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M.,
RA   Nash J.H.E.;
RT   "The complete genome sequence of Actinobacillus pleuropneumoniae L20
RT   (serotype 5b).";
RL   J. Bacteriol. 190:1495-1496(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000569; ABN74686.1; -; Genomic_DNA.
DR   RefSeq; WP_009874585.1; NC_009053.1.
DR   AlphaFoldDB; A3N2Q0; -.
DR   SMR; A3N2Q0; -.
DR   STRING; 416269.APL_1602; -.
DR   EnsemblBacteria; ABN74686; ABN74686; APL_1602.
DR   KEGG; apl:APL_1602; -.
DR   PATRIC; fig|416269.6.peg.1668; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001432; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335104"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95571 MW;  14F0361405816C88 CRC64;
     MTQDLSKHTP MMAQYLQLKA QNPDILLFYR MGDFYELFYD DAKKAAALLD ISLTKRGASA
     GEPIPMAGVP YHAVEGYLAK LVSLGESVAI CEQIGDPATS KGPVERKVVR IVTPGTVSDE
     ALLPERQDNL VAAIYEEKGV FAIATLDMTS GRFLITELPN KEALAAELQR LLPAEILYAE
     DFSAAEILNN YKGLRRRPVW EFELVTAINL LNRQFGTQSL AGFGVEKAVV ALCAAGCVLH
     YAQETQRTAL PHINSIHLAQ NSDTILLDAA TRRNLELTQN LAGGTENTLA AVLDKCVTPM
     GSRLLKRWIH QPIRDLEKLK KRQDIIDTLQ KEQRIEPLQP LLQNVGDMER ILARVALRSA
     RPRDLTHLRT ALAQLPDIAK NAKNLTASLD ALVAQIGDFS ELHALLKRAI IETPPQLIRD
     GGVIAEGYNA ELDEWRELSA GATQYLENLE IREREATGID TLKIGFNAVH GYYIQISQGQ
     AHKAPMHYVR RQTLKNAERY IIPELKTYED KVLKAKGASL ALEKQLYDEL FDLLMPRLGE
     MQLAAMALSE LDVLTNLAER AESLNYVRPT FSLQRGVNIK GGRHPVVEQV LKDPFIANPV
     FLNAQRHLLV VTGPNMGGKS TYMRQIALIS LMAYIGSFVP ADSAEIGALD RIFTRIGASD
     DLASGRSTFM VEMTEMANIL HQATEKSLVL IDEIGRGTST YDGLSLAWAC AEWLAKKTQS
     LTLFATHYFE LTSLPSQLKG VANVHLDARE HQDSIVFMHS VQEGAASKSY GLAVAALAGV
     PKQVIQLAKQ RLAHLEEISL QTKEAHDNPQ GDLLFAADLQ ETPQIQPLVA QQSELEKALI
     SIDPDELTPR QALEALYRLK KLMA