ID   MUTS_ACTPJ              Reviewed;         864 AA.
AC   B0BRS8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=APJL_1635;
OS   Actinobacillus pleuropneumoniae serotype 3 (strain JL03).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=434271;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JL03;
RX   PubMed=18197260; DOI=10.1371/journal.pone.0001450;
RA   Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W.,
RA   Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T.,
RA   Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S.,
RA   Zhao G.-P., Chen H.;
RT   "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of
RT   serotype 3 prevalent in China.";
RL   PLoS ONE 3:E1450-E1450(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000687; ABY70187.1; -; Genomic_DNA.
DR   RefSeq; WP_012263308.1; NC_010278.1.
DR   AlphaFoldDB; B0BRS8; -.
DR   SMR; B0BRS8; -.
DR   EnsemblBacteria; ABY70187; ABY70187; APJL_1635.
DR   KEGG; apj:APJL_1635; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008547; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335103"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95612 MW;  7300DFDE62836BCC CRC64;
     MTQDLSKHTP MMAQYLQLKA QNPDILLFYR MGDFYELFYD DAKKAAALLD ISLTKRGASA
     GEPIPMAGVP YHAVEGYLAK LVSLGESVAI CEQIGDPATS KGPVERKVVR IVTPGTVSDE
     ALLPERQDNL VAAIYEEKGV FAIATLDMTS GRFLITELPN KEALAAELQR LQLAEILYAE
     DFSAAEILNN YKGLRRRPVW EFELVTAINL LNRQFGTQSL AGFGVEKAVV ALCAAGCVLH
     YAQETQRTAL PHINSIHLAQ NSDTVLLDAA TRRNLELTQN LAGGTENTLA AVLDKCVTPM
     GSRLLKRWIH QPIRDLEKLK KRQDIIDTLQ KEQRIEPLQP LLQNVGDMER ILARVALRSA
     RPRDLTRLRT ALAQLPDIAK NAKNLTASLD ALVAQIGDFS ELHALLERAI IETPPQLIRD
     GGVIAEGYNA ELDEWRELSA GATQYLENLE IREREATGID TLKIGFNAVH GYYIQISQGQ
     AHKAPMHYVR RQTLKNAERY IIPELKTYED KVLKAKGASL ALEKQLYDEL FDLLMPRLGE
     MQLAAMALSE LDVLTNLAER AESLNYVRPT FSLQRGVNIK GGRHPVVEQV LKDPFIANPV
     FLNAQRHLLV VTGPNMGGKS TYMRQIALIS LMAYIGSFVP ADSAEIGALD RIFTRIGASD
     DLASGRSTFM VEMTEMANIL HQATENSLVL IDEIGRGTST YDGLSLAWAC AEWLAKKTQS
     LTLFATHYFE LTSLPSQLKG VANVHLDARE HQDSIVFMHS VQEGAASKSY GLAVAALAGV
     PKQVIQLAKQ RLAHLEEISL QTKEAHDNPQ GDLLFAADLQ ETPQIQPLVA QQSELEKALM
     SIDPDELTPR QALEALYRLK KLMA