ID   MUTS_ACTSZ              Reviewed;         858 AA.
AC   A6VL76;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Asuc_0345;
OS   Actinobacillus succinogenes (strain ATCC 55618 / DSM 22257 / CCUG 43843 /
OS   130Z).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Actinobacillus.
OX   NCBI_TaxID=339671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55618 / DSM 22257 / CCUG 43843 / 130Z;
RX   PubMed=21118570; DOI=10.1186/1471-2164-11-680;
RA   McKinlay J.B., Laivenieks M., Schindler B.D., McKinlay A.A.,
RA   Siddaramappa S., Challacombe J.F., Lowry S.R., Clum A., Lapidus A.L.,
RA   Burkhart K.B., Harkins V., Vieille C.;
RT   "A genomic perspective on the potential of Actinobacillus succinogenes for
RT   industrial succinate production.";
RL   BMC Genomics 11:680-680(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000746; ABR73723.1; -; Genomic_DNA.
DR   RefSeq; WP_011978998.1; NC_009655.1.
DR   AlphaFoldDB; A6VL76; -.
DR   SMR; A6VL76; -.
DR   STRING; 339671.Asuc_0345; -.
DR   EnsemblBacteria; ABR73723; ABR73723; Asuc_0345.
DR   KEGG; asu:Asuc_0345; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001114; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..858
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075551"
FT   BINDING         611..618
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   858 AA;  95600 MW;  A8990A903F423814 CRC64;
     MPNFDAHTPM MKQYLTIKAE NPDILLFYRM GDFYEMFYDD AKKAAALLDI SLTKRGQSAG
     RPIPMAGVPY HAVEGYLAKL VQLGESVAIC EQIGDPAASK GPVERKIVRI VTPGTVSDEN
     LLPERQDNLL VAVYQEKDRF GLASLDMSSG RFQIAEAENA ETLHAELQRL QPAELLYSED
     FSEMAIIEQT KGLRRRPIWE FELGTAVQLL NRQFGTKDLK AFGVEKAVLG LCAAGCLFQY
     AKETQRTALP HIKSISLVQN SDTVQLDAAT RRNLELTRNL SGGTENTLAS VLDKCVTPMG
     SRLLKRWIHQ PIRKIQKLRQ RQQTIAAILQ DDLIDELQPL LRQVGDMERI LARVALRTAR
     PRDLTRLRTA LEQLPQLQQI IKTLQNLTAL SQPMGEFAEL CDLLQRAIID SPPLLIRDGG
     VIAPGYHAEL DEWRSLADGA TQYLADLERR ERESTGIDTL KIGYNAVHGY YIQISQGQAH
     NAPMHYVRRQ TLKNAERYII PELKTYEDKV LKAKGAALAL EKQLYEEIFD QLLPHLAALQ
     LSSMTLAELD VLTNLAERAE TLNYVCPEFS PEIGVEIQNG RHPVVEQVLK EPFIANPVCL
     NPQRRLLVIT GPNMGGKSTY MRQTALITLM AYMGGFVPAE RAVIGPIDRI FTRIGASDDL
     ASGRSTFMVE MTEMANILHQ ATADSLVLID EIGRGTSTYD GLSLAWACAE WLAKKLRSLT
     LFATHYFELT VLPEQFAGTA NVHLDALEHD NTIAFMHAVQ DGAASKSYGL AVAALAGVPQ
     QVIKLAKQKL AQLEKLSAQS ADQKLQDLRT LHQMQGELAL MEEDDGKNAA LEMLEKLDPD
     ELSPKQALAY LYQLKTLL