ID   MUTS_AERHH              Reviewed;         860 AA.
AC   A0KPG5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=AHA_3718;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000462; ABK38264.1; -; Genomic_DNA.
DR   RefSeq; WP_011707433.1; NC_008570.1.
DR   RefSeq; YP_858166.1; NC_008570.1.
DR   AlphaFoldDB; A0KPG5; -.
DR   SMR; A0KPG5; -.
DR   STRING; 380703.AHA_3718; -.
DR   EnsemblBacteria; ABK38264; ABK38264; AHA_3718.
DR   KEGG; aha:AHA_3718; -.
DR   PATRIC; fig|380703.7.peg.3691; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..860
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335105"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   860 AA;  95602 MW;  C2E97059D3FD5A49 CRC64;
     MTAQHQATGT APGANLSAHT PMMQQYLTLK AENPEILLFY RMGDFYELFY DDARKASQLL
     DISLTKRGQS AGSPIPMAGV PYHAIEGYLA KLVQLGESAA ICEQVGDPAT SKGPVERKVI
     RIITPGTVSD EALLSERQDN LIAAVYHDGR RFGYGTMDIG SGRFFINQFE KEETLLAELQ
     RTNPAELLYP ESFTFLHHVE GRRGLRRRPE WEFELGTARK LLCQQFGTQD LVGFGVEQSE
     TALCAAGCLM QYVKDTQRTA LPHIRSVRLE QPDHAVIMDA ATRRNLELTQ NLAGGHDNTL
     SAVLDCTATP MGSRLLKRWI HQPIRDQVIL KGRQSTIKEL IEQNLYDELG GLLRQVGDVE
     RVLARLALRS ARPRDLTRLR QAFAQLPELQ RLLAESEHEA VQQLRERAST FPELLDLLER
     AVMEVPPVLI RDGGVIRDGF NQELDELRDL ANGATASLAR IEERERLLTG INTLKVGYNK
     VHGFYIEVSR ANSHLVPAHY IRRQTLKNNE RYIIDELKKY EDKVLTAQAQ ALALEKRLYE
     ELLDALLPHL GDLQESAAAL AELDVLANLA ERAETLDYRC PTLIDEDQIL IEAGRHPVVE
     QVMTDPFIAN PINLQRSRRM LIITGPNMGG KSTYMRQTAL IVLLAHIGAF VPADSARIGP
     IDRIFTRIGA SDDLASGRST FMVEMTETAN ILNNATARSL VLMDEIGRGT STYDGLSLAW
     ACAEQLASKI GAYTLFATHY FELTRLPELM EGLANVHLDA VEHGDTIAFM HAVQEGAASR
     SYGLQVAALA GVPKSVIQQA RHKLHELESA TPVAAGESRP APVAMAPQSH PVVDELEAVR
     PDELTPRQAL DLLYRLKQML