ID   MUTS_AERS4              Reviewed;         851 AA.
AC   A4SIL2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=ASA_0568;
OS   Aeromonas salmonicida (strain A449).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A449;
RX   PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA   Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA   Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA   Brown L.L.;
RT   "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT   the evolution of a fish pathogen.";
RL   BMC Genomics 9:427-427(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000644; ABO88734.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4SIL2; -.
DR   SMR; A4SIL2; -.
DR   STRING; 382245.ASA_0568; -.
DR   EnsemblBacteria; ABO88734; ABO88734; ASA_0568.
DR   KEGG; asa:ASA_0568; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000225; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..851
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335106"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   851 AA;  95070 MW;  871C17A319B90390 CRC64;
     MINIENIQQH TPMMQQYLGL KAENPEILLF YRMGDFYELF YDDARKASQL LDISLTKRGQ
     SAGNPIPMAG VPYHAIEGYL AKLIQLGESA AICEQVGDPA TSKGPVERKV IRIITPGTVS
     DEALLSERQD NLIAAVYHDG RRFGYGTMDI GSGRFFINQF DKEETLLAEL QRTNPAELLY
     PESFAFLQHV EGRRGLRRRP EWEFELGTAR KLLCQQFGTQ DLVGFGVDKS ETALCAAGCL
     MQYVKDTQRT ALPHIRSVRL EQPDHAVIMD AATRRNLELT QNLAGGYENT LAEVLDRTAT
     PMGSRLLKRW IHQPIRDRVI LKGRQSTIKE LIEQNLYDEL GALLRQVGDV ERVLARLALR
     SARPRDLTRL RQAFAQLPEL QRLLADNRHE AVQQLAERAS TFPELLSLLE RAVMEVPPVL
     IRDGGVIRDG FNQELDELRD LANGATASLV RIEEREKALT GINTLKVGYN RVHGFYIEVS
     RANSHLVPAH YIRRQTLKNN ERYIIDELKK YEDKVLTAQA QALALEKRLY EELLDTLLPH
     LGDLQESASA LAELDVLANL AERAETLDYR CPTLIDEDQI LIEAGRHPVV EQVMSDPFIA
     NPIRLERERR MLIITGPNMG GKSTYMRQTA LIVLLAHIGA FVPADSAHIG PIDRIFTRIG
     ASDDLASGRS TFMVEMTETA NILNNATARS LVLMDEIGRG TSTYDGLSLA WACAEQLASK
     IGAYTLFATH YFELTRLPEL MSGLANVHLD AVEHGDTIAF MHAVQEGAAS RSYGLQVAAL
     AGVPKSVINQ ARHKLAELES ATPLATGEVR PASIPLLPQS HPVVDELEAV RPDELTPRQA
     LDLVYRLKQM L