ID   MUTS_AGRFC              Reviewed;         904 AA.
AC   Q8UIF2;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Atu0345;
GN   ORFNames=AGR_C_602;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK86162.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE007869; AAK86162.2; ALT_INIT; Genomic_DNA.
DR   PIR; A97401; A97401.
DR   PIR; AI2618; AI2618.
DR   RefSeq; NP_353377.2; NC_003062.2.
DR   RefSeq; WP_006310190.1; NC_003062.2.
DR   AlphaFoldDB; Q8UIF2; -.
DR   SMR; Q8UIF2; -.
DR   STRING; 176299.Atu0345; -.
DR   EnsemblBacteria; AAK86162; AAK86162; Atu0345.
DR   KEGG; atu:Atu0345; -.
DR   PATRIC; fig|176299.10.peg.336; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..904
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115062"
FT   BINDING         655..662
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   904 AA;  98204 MW;  5D5D786D1FBD99AE CRC64;
     MTDVLTTASL ISEESRATAT PMMEQYIEIK ANNPGSLLFY RMGDFYELFF DDAVEASRAL
     GITLTKRGQH MGHDIPMCGV PVHAADDYLQ KLILRGYRVA VCEQIEDPAE AKKRGSKSVV
     KRDVVRLVTP GTLTEEKLLS PTESNYLMAL ARIRGSAEAQ FALAWIDIST GVFRLAETTL
     TRLLADIWRI DPRELIVADS LFHDEELRPV FDVLGRVAVP QPAILFDSAV AEGRIARYFN
     VSTLDGFGTF SRVEMAAAAA AVAYVEKTQI AERPPLGAPE RESAASTLFI DPATRANLEL
     VKTLSGDRDG SLLHALNRTV TGGGARLLAE RLMSPLTDPE RINARLDAVA YLIDDVSLCD
     GLRDALKHVA DMPRALSRLA LERGGPRDLG AIRQGLVSAE KIAVILDGGL LPDELAKALR
     DLKALPGALE AMLGSMLADD LPLLKRDGGF LREGANPELD EVRALRDQSR RVIAGLQLQY
     ADETGIKSLK IKHNNVLGYF IEVTAGNADV MMATDEAKAR FIHRQTMAGA MRFTTTELAD
     LESRIANAAA EALTMELEAF ERMVEAVVQQ AEAIKAGALA LAVIDVASSL AYLATEQAYC
     RPIVDASMTF SIKGGRHPVV EQALRRQSAG PFIANNCDLS AVNGGKNGAI WLLTGPNMGG
     KSTFLRQNAL IAILAQIGSF VPAEAAHIGV VDRLFSRVGA SDDLARGRST FMVEMVETAA
     ILNQATDRSL VILDEIGRGT ATFDGLSIAW AAVEHLHEVN RCRGLFATHF HELTVLSEKL
     GRLSNATMRV KEWEGDVIFL HEVGPGAADR SYGIQVARLA GLPASVVERA REVLTKLEDA
     DRKNPASQLI DDLPLFQIAV RREETRKAGP SKVEEALKSF NPDEMTPREA LDALYALKKE
     LGKA